CHL1 (cell adhesion molecule L1 like)

2003-05-01  

Identity

HGNC
CHL1
LOCATION
3p26.3
LOCUSID
10752
ALIAS
CALL,L1CAM2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10752
MIM: 607416
HGNC: 1939
Ensembl: ENSG00000134121

Variants:

dbSNP: 10752
ClinVar: 10752
TCGA: ENSG00000134121
COSMIC: CHL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134121ENST00000256509O00533
ENSG00000134121ENST00000397491O00533
ENSG00000134121ENST00000421198C9JW79
ENSG00000134121ENST00000427688C9JEY3
ENSG00000134121ENST00000435603C9J905
ENSG00000134121ENST00000445697H7C0J0
ENSG00000134121ENST00000449294C9JH37
ENSG00000134121ENST00000453040F8WEP4
ENSG00000134121ENST00000620033A0A087X0M8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
CHL1 interactionsREACTOMER-HSA-447041

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
330544692022Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.0
352625252022Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.3
330544692022Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.0
352625252022Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.3
316143702021Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function.11
334530202021Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.3
347183362021Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.13
316143702021Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function.11
334530202021Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.3
347183362021Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.13
325573222020Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.10
333264882020Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.3
325573222020Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.10
333264882020Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.3
306223392019Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma.15

Citation

Dessen P

CHL1 (cell adhesion molecule L1 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40076