Identity
HGNC
LOCATION
10q24.31
LOCUSID
ALIAS
BPS2,IKBKA,IKK-alpha,IKK1,IKKA,NFKBIKA,TCF16
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1147
MIM: 600664
HGNC: 1974
Ensembl: ENSG00000213341
Variants:
dbSNP: 1147
ClinVar: 1147
TCGA: ENSG00000213341
COSMIC: CHUK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000213341 | ENST00000370397 | O15111 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38565741 | 2024 | Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance. | 0 |
| 38775480 | 2024 | GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB. | 0 |
| 38565741 | 2024 | Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance. | 0 |
| 38775480 | 2024 | GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB. | 0 |
| 36515432 | 2023 | IKKα kinase silencing increases doxorubicin-induced apoptosis through regulation of oxidative DNA damage response in colon cancer cells. | 0 |
| 36528060 | 2023 | The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism. | 4 |
| 37080443 | 2023 | IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling. | 0 |
| 37100289 | 2023 | The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection. | 1 |
| 36515432 | 2023 | IKKα kinase silencing increases doxorubicin-induced apoptosis through regulation of oxidative DNA damage response in colon cancer cells. | 0 |
| 36528060 | 2023 | The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism. | 4 |
| 37080443 | 2023 | IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling. | 0 |
| 37100289 | 2023 | The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection. | 1 |
| 35029639 | 2022 | IKKα plays a major role in canonical NF-κB signalling in colorectal cells. | 5 |
| 35173303 | 2022 | Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. | 2 |
| 35029639 | 2022 | IKKα plays a major role in canonical NF-κB signalling in colorectal cells. | 5 |
Citation
Dessen P
CHUK (component of inhibitor of nuclear factor kappa B kinase complex)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/40081/chuk-(component-of-inhibitor-of-nuclear-factor-kappa-b-kinase-complex)
