Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9391
MIM: 604333
HGNC: 14280
Ensembl: ENSG00000144021
Variants:
dbSNP: 9391
ClinVar: 9391
TCGA: ENSG00000144021
COSMIC: CIAO1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000144021 | ENST00000488633 | O76071 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Cytosolic iron-sulfur cluster assembly | REACTOME | R-HSA-2564830 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38950322 | 2024 | CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymes. | 0 |
| 38950322 | 2024 | CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymes. | 0 |
| 34569959 | 2021 | A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer's Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor. | 0 |
| 34569959 | 2021 | A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer's Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor. | 0 |
| 32632277 | 2020 | Structural insights into Fe-S protein biogenesis by the CIA targeting complex. | 10 |
| 32632277 | 2020 | Structural insights into Fe-S protein biogenesis by the CIA targeting complex. | 10 |
| 29309586 | 2018 | Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. | 24 |
| 29309586 | 2018 | Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. | 24 |
| 28615450 | 2017 | Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. | 15 |
| 28615450 | 2017 | Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. | 15 |
| 27235625 | 2016 | Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. | 4 |
| 27235625 | 2016 | Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. | 4 |
| 24245804 | 2014 | Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. | 52 |
| 24245804 | 2014 | Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. | 52 |
| 23891004 | 2013 | Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. | 73 |
Citation
Dessen P
CIAO1 (cytosolic iron-sulfur assembly component 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40082/ciao1
