CLK3 (CDC like kinase 3)

2003-11-01  

Identity

HGNC
CLK3
LOCATION
15q24.1
LOCUSID
1198
ALIAS
PHCLK3,PHCLK3/152
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1198
MIM: 602990
HGNC: 2071
Ensembl: ENSG00000179335

Variants:

dbSNP: 1198
ClinVar: 1198
TCGA: ENSG00000179335
COSMIC: CLK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179335ENST00000345005P49761
ENSG00000179335ENST00000395066P49761
ENSG00000179335ENST00000483723P49761
ENSG00000179335ENST00000562389H3BRT8
ENSG00000179335ENST00000562670H3BQR7
ENSG00000179335ENST00000563297H3BTW9
ENSG00000179335ENST00000563418H3BRW2
ENSG00000179335ENST00000563842H3BRE4
ENSG00000179335ENST00000564096H3BVF8
ENSG00000179335ENST00000564468H3BNC8
ENSG00000179335ENST00000566126H3BUL5
ENSG00000179335ENST00000566926H3BNQ5
ENSG00000179335ENST00000568139H3BQG1
ENSG00000179335ENST00000568488H3BV35
ENSG00000179335ENST00000569063H3BRK0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388858062024CLK3 positively promoted colorectal cancer proliferation by activating IL-6/STAT3 signaling.0
388858062024CLK3 positively promoted colorectal cancer proliferation by activating IL-6/STAT3 signaling.0
324534202020Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism.29
324534202020Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism.29
318317282019The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression.52
318317282019The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression.52
296250702018A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.29
296250702018A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.29
191684422009Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.26
194265922009[Expression of cell cycle molecules in human azoospermic testes].0
191684422009Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.26
194265922009[Expression of cell cycle molecules in human azoospermic testes].0

Citation

Dessen P

CLK3 (CDC like kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40104/clk3