CRMP1 (collapsin response mediator protein 1)

2003-02-01  

Identity

HGNC
CRMP1
LOCATION
4p16.2
LOCUSID
1400
ALIAS
CRMP-1,DPYSL1,DRP-1,DRP1,ULIP-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1400
MIM: 602462
HGNC: 2365
Ensembl: ENSG00000072832

Variants:

dbSNP: 1400
ClinVar: 1400
TCGA: ENSG00000072832
COSMIC: CRMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072832ENST00000324989Q14194
ENSG00000072832ENST00000324989X5DNI1
ENSG00000072832ENST00000397890Q14194
ENSG00000072832ENST00000512574E9PD68

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365117802022Monoallelic CRMP1 gene variants cause neurodevelopmental disorder.4
365117802022Monoallelic CRMP1 gene variants cause neurodevelopmental disorder.4
304663682019Overexpression of Collapsin Response Mediator Protein 1 Inhibits Human Trophoblast Cells Proliferation, Migration, and Invasion.2
304663682019Overexpression of Collapsin Response Mediator Protein 1 Inhibits Human Trophoblast Cells Proliferation, Migration, and Invasion.2
296663692018Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder.9
296663692018Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder.9
273211792017Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization.24
278641462017MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1.6
286301442017CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex.12
273211792017Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization.24
278641462017MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1.6
286301442017CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex.12
255268602016CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.9
265985192016Collapsin Response Mediator Protein-1 Regulates Arp2/3-dependent Actin Assembly.7
280259992016miR-200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating cytoplasmic collapsin response mediator protein-1.12

Citation

Dessen P

CRMP1 (collapsin response mediator protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40151/tumors-explorer/js/js/template.js