Identity
HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
BAM,BMH,CDLS3,CSPG6,HCAP,SMC3L1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9126
MIM: 606062
HGNC: 2468
Ensembl: ENSG00000108055
Variants:
dbSNP: 9126
ClinVar: 9126
TCGA: ENSG00000108055
COSMIC: SMC3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108055 | ENST00000361804 | Q9UQE7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38297832 | 2024 | Heterozygous loss-of-function SMC3 variants are associated with variable growth and developmental features. | 1 |
| 38297832 | 2024 | Heterozygous loss-of-function SMC3 variants are associated with variable growth and developmental features. | 1 |
| 37641131 | 2023 | SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. | 0 |
| 38017479 | 2023 | RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma. | 1 |
| 37641131 | 2023 | SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. | 0 |
| 38017479 | 2023 | RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma. | 1 |
| 35587378 | 2022 | Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model. | 7 |
| 35587378 | 2022 | Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model. | 7 |
| 34621263 | 2021 | Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. | 4 |
| 34621263 | 2021 | Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. | 4 |
| 30323357 | 2019 | SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia. | 5 |
| 30323357 | 2019 | SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia. | 5 |
| 29452578 | 2018 | Clinical and genetic study of 20 patients from China with Cornelia de Lange syndrome. | 2 |
| 29852353 | 2018 | Hydrogen gas inhibits lung cancer progression through targeting SMC3. | 42 |
| 29452578 | 2018 | Clinical and genetic study of 20 patients from China with Cornelia de Lange syndrome. | 2 |
Citation
Dessen P
SMC3 (structural maintenance of chromosomes 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40175/smc3
