CTSD (cathepsin D)

2003-06-01  

Identity

HGNC
CTSD
LOCATION
11p15.5
LOCUSID
1509
ALIAS
CLN10,CPSD,HEL-S-130P
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1509
MIM: 116840
HGNC: 2529
Ensembl: ENSG00000117984

Variants:

dbSNP: 1509
ClinVar: 1509
TCGA: ENSG00000117984
COSMIC: CTSD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117984ENST00000236671P07339
ENSG00000117984ENST00000236671V9HWI3
ENSG00000117984ENST00000367196F8W787
ENSG00000117984ENST00000429746H7C1V0
ENSG00000117984ENST00000433655F8WD96
ENSG00000117984ENST00000438213C9JH19
ENSG00000117984ENST00000636571A0A1B0GW44
ENSG00000117984ENST00000636843A0A1B0GWE8
ENSG00000117984ENST00000637381A0A1B0GV01
ENSG00000117984ENST00000637387A0A1B0GVP3
ENSG00000117984ENST00000637815A0A1B0GV23
ENSG00000117984ENST00000637915A0A1B0GVD5

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
ApoptosisKEGGko04210
Autophagy - animalKEGGhsa04140
ApoptosisKEGGhsa04210
LysosomeKEGGko04142
LysosomeKEGGhsa04142
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Collagen degradationREACTOMER-HSA-1442490
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381636472024Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.0
384207562024Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes.0
389179622024CTSD upregulation as a key driver of spinal ligament abnormalities in spinal stenosis.0
389284162024Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons.0
381636472024Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.0
384207562024Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes.0
389179622024CTSD upregulation as a key driver of spinal ligament abnormalities in spinal stenosis.0
389284162024Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons.0
372013572023Maintenance of cathepsin D-dependent autophagy-lysosomal function protects against cardiac ischemia/reperfusion injury.0
372530922023CircRNA-406918 enhances the degradation of advanced glycation end products in photoaged human dermal fibroblasts via targeting cathepsin D.0
377943572023Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia.0
378269482023A novel function by cathepsin D in degradation of nucleic acids.0
372013572023Maintenance of cathepsin D-dependent autophagy-lysosomal function protects against cardiac ischemia/reperfusion injury.0
372530922023CircRNA-406918 enhances the degradation of advanced glycation end products in photoaged human dermal fibroblasts via targeting cathepsin D.0
377943572023Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia.0

Citation

Dessen P

CTSD (cathepsin D)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40203/favicon/favicon-16x16.png