CTSK (cathepsin K)

2003-06-01  

Identity

HGNC
CTSK
LOCATION
1q21.3
LOCUSID
1513
ALIAS
CTS02,CTSO,CTSO1,CTSO2,PKND,PYCD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1513
MIM: 601105
HGNC: 2536
Ensembl: ENSG00000143387

Variants:

dbSNP: 1513
ClinVar: 1513
TCGA: ENSG00000143387
COSMIC: CTSK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143387ENST00000271651P43235
ENSG00000143387ENST00000443913Q5QP40

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Toll-like receptor signaling pathwayKEGGko04620
ApoptosisKEGGhsa04210
Toll-like receptor signaling pathwayKEGGhsa04620
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490

References

Pubmed IDYearTitleCitations
387032042024Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.0
387032042024Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.0
366972522023Lung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen.1
379383232023mTOR eosinophilic renal cell carcinoma: a distinctive tumor characterized by mTOR mutation, loss of chromosome 1, cathepsin-K expression, and response to target therapy.1
366972522023Lung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen.1
379383232023mTOR eosinophilic renal cell carcinoma: a distinctive tumor characterized by mTOR mutation, loss of chromosome 1, cathepsin-K expression, and response to target therapy.1
344331822022Cathepsin K is Superior to HMB45 for the Diagnosis of Pulmonary Lymphangioleiomyomatosis.1
353152542022Clinical and genetic characterization of three Russian patients with pycnodysostosis due to pathogenic variants in the CTSK gene.4
361380182022Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer.16
344331822022Cathepsin K is Superior to HMB45 for the Diagnosis of Pulmonary Lymphangioleiomyomatosis.1
353152542022Clinical and genetic characterization of three Russian patients with pycnodysostosis due to pathogenic variants in the CTSK gene.4
361380182022Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer.16
332274972021Human cathepsin X/Z is a biologically active homodimer.6
334290752021Clinical and genetic evaluation of Danish patients with pycnodysostosis.8
334457322021Elevated Expression of Cathepsin K in Periodontal Ligament Fibroblast by Inflammatory Cytokines Accelerates Osteoclastogenesis via Paracrine Mechanism in Periodontal Disease.4

Citation

Dessen P

CTSK (cathepsin K)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40207