CUL2 (cullin 2)

2003-02-01  

Identity

HGNC
CUL2
LOCATION
10p11.21
LOCUSID
8453
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8453
MIM: 603135
HGNC: 2552
Ensembl: ENSG00000108094

Variants:

dbSNP: 8453
ClinVar: 8453
TCGA: ENSG00000108094
COSMIC: CUL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108094ENST00000374746Q5T2B5
ENSG00000108094ENST00000374748Q13617
ENSG00000108094ENST00000374748A0A140VKB1
ENSG00000108094ENST00000374749Q13617
ENSG00000108094ENST00000374749A0A140VKB1
ENSG00000108094ENST00000374751Q13617
ENSG00000108094ENST00000374751A0A140VKB1
ENSG00000108094ENST00000374754Q5T2B7
ENSG00000108094ENST00000421317Q13617
ENSG00000108094ENST00000537177A0A0A0MTN0
ENSG00000108094ENST00000626172Q5T2B5
ENSG00000108094ENST00000673636A0A140VKB1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Renal cell carcinomaKEGGko05211
Ubiquitin mediated proteolysisKEGGhsa04120
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
ECV complexKEGGhsa_M00383
HIF-1 signaling pathwayKEGGhsa04066
ECV complexKEGGM00383
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
373970072023MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.2
373970072023MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.2
346553622022MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.2
347171912022Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.3
356506032022CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.27
356958912022A close shave: How SARS-CoV-2 induces the loss of cilia.1
346553622022MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.2
347171912022Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.3
356506032022CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.27
356958912022A close shave: How SARS-CoV-2 induces the loss of cilia.1
329189702021Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.5
338279882021ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.19
341957922021Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.4
329189702021Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.5
338279882021ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.19

Citation

Dessen P

CUL2 (cullin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40212