Identity
HGNC
LOCATION
Xq24
LOCUSID
ALIAS
CUL-4B,MRXHF2,MRXS15,MRXSC,SFM2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8450
MIM: 300304
HGNC: 2555
Ensembl: ENSG00000158290
Variants:
dbSNP: 8450
ClinVar: 8450
TCGA: ENSG00000158290
COSMIC: CUL4B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158290 | ENST00000336592 | K4DI93 |
| ENSG00000158290 | ENST00000371322 | Q13620 |
| ENSG00000158290 | ENST00000371323 | A6NE76 |
| ENSG00000158290 | ENST00000404115 | Q13620 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38254314 | 2024 | Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis. | 0 |
| 38331954 | 2024 | CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. | 0 |
| 38937308 | 2024 | Association of CUL4B with the pathogenesis of age-related cataract. | 0 |
| 38254314 | 2024 | Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis. | 0 |
| 38331954 | 2024 | CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. | 0 |
| 38937308 | 2024 | Association of CUL4B with the pathogenesis of age-related cataract. | 0 |
| 36476360 | 2023 | CUL4B-associated epilepsy: Report of a novel truncating variant promoting drug-resistant seizures and systematic review of the literature. | 2 |
| 36939378 | 2023 | MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. | 4 |
| 37158446 | 2023 | Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. | 2 |
| 37365982 | 2023 | The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs. | 3 |
| 37686215 | 2023 | Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma. | 1 |
| 36476360 | 2023 | CUL4B-associated epilepsy: Report of a novel truncating variant promoting drug-resistant seizures and systematic review of the literature. | 2 |
| 36939378 | 2023 | MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. | 4 |
| 37158446 | 2023 | Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. | 2 |
| 37365982 | 2023 | The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs. | 3 |
Citation
Dessen P
CUL4B (cullin 4B)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40215/cul4b
