CXCL1 (C-X-C motif chemokine ligand 1)

2003-02-01  

Identity

HGNC
CXCL1
LOCATION
4q13.3
LOCUSID
2919
ALIAS
FSP,GRO1,GROa,MGSA,MGSA-a,NAP-3,SCYB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2919
MIM: 155730
HGNC: 4602
Ensembl: ENSG00000163739

Variants:

dbSNP: 2919
ClinVar: 2919
TCGA: ENSG00000163739
COSMIC: CXCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163739ENST00000395761P09341

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cytokine-cytokine receptor interactionKEGGhsa04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
381281162024Cxcl1 monomer-dimer equilibrium controls neutrophil extravasation.1
383934652024The role of CXCL1 in crosstalk between endocrine resistant breast cancer and fibroblast.0
384544432024Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2.0
386543562024Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling.1
386703072024Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma metastasis via enhancing CXCL1-dependent infiltration of tumor-associated neutrophils.1
387244652024CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.0
381281162024Cxcl1 monomer-dimer equilibrium controls neutrophil extravasation.1
383934652024The role of CXCL1 in crosstalk between endocrine resistant breast cancer and fibroblast.0
384544432024Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2.0
386543562024Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling.1
386703072024Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma metastasis via enhancing CXCL1-dependent infiltration of tumor-associated neutrophils.1
387244652024CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.0
352584072023Monocyte secretory profiling in a clinical and MEFV genotype-characterized cohort of Danish familial Mediterranean fever patients: diagnostic potential of CCL1 and CXCL1.0
358690372023CXCL1 confers a survival advantage in Kaposi's sarcoma-associated herpesvirus-infected human endothelial cells through STAT3 phosphorylation.5
361690922023Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.9

Citation

Dessen P

CXCL1 (C-X-C motif chemokine ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40217