Identity
HGNC
LOCATION
2q22.1
LOCUSID
ALIAS
CD184,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7852
MIM: 162643
HGNC: 2561
Ensembl: ENSG00000121966
Variants:
dbSNP: 7852
ClinVar: 7852
TCGA: ENSG00000121966
COSMIC: CXCR4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000121966 | ENST00000241393 | P61073 |
| ENSG00000121966 | ENST00000409817 | P61073 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 27503580 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 27503580 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37757768 | 2024 | ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway. | 1 |
| 37890573 | 2024 | Chemokine receptor CXCR4 interacts with nuclear receptor Nur77 and promote glioma invasion and progression. | 1 |
| 37972448 | 2024 | CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis. | 0 |
| 37979093 | 2024 | Clinical, biological, electrophysiological and therapeutic profile of patients with anti-MAG neuropathy according to MYD88(L265P) and CXCR4 mutations and underlying haemopathy. | 0 |
| 38220479 | 2024 | C-X-C motif chemokine receptor 4 inhibition promotes the effect of plantamajoside in hepatocellular carcinoma. | 0 |
| 38306953 | 2024 | CXCL12-CXCR4 mediates CD57(+) CD8(+) T cell responses in the progression of type 1 diabetes. | 2 |
| 38366101 | 2024 | CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study. | 0 |
| 38430337 | 2024 | Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala. | 0 |
| 38442908 | 2024 | CXCR4 WHIM syndrome is a cancer predisposition condition for virus-induced malignancies. | 0 |
| 38472446 | 2024 | Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages. | 0 |
| 38487536 | 2024 | Intratumoral CXCR4(hi) neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma. | 0 |
| 38524630 | 2024 | Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms. | 0 |
| 38547061 | 2024 | The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells. | 1 |
| 38579048 | 2024 | The CXCR4 might be a potential biomarker for esophageal squamous cell carcinoma: A meta-analysis. | 0 |
| 38727318 | 2024 | Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients. | 0 |
Citation
Dessen P
CXCR4 (C-X-C motif chemokine receptor 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40225/cxcr4
