CXCR4 (C-X-C motif chemokine receptor 4)

2003-02-01  

Identity

HGNC
CXCR4
LOCATION
2q22.1
LOCUSID
7852
ALIAS
CD184,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,WHIMS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7852
MIM: 162643
HGNC: 2561
Ensembl: ENSG00000121966

Variants:

dbSNP: 7852
ClinVar: 7852
TCGA: ENSG00000121966
COSMIC: CXCR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121966ENST00000241393P61073
ENSG00000121966ENST00000409817P61073

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Axon guidanceKEGGko04360
Leukocyte transendothelial migrationKEGGko04670
Cytokine-cytokine receptor interactionKEGGhsa04060
Axon guidanceKEGGhsa04360
Leukocyte transendothelial migrationKEGGhsa04670
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Binding and entry of HIV virionREACTOMER-HSA-173107
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalClinicalAnnotationassociatedPD27503580
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD27503580

References

Pubmed IDYearTitleCitations
377577682024ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway.1
378905732024Chemokine receptor CXCR4 interacts with nuclear receptor Nur77 and promote glioma invasion and progression.1
379724482024CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis.0
379790932024Clinical, biological, electrophysiological and therapeutic profile of patients with anti-MAG neuropathy according to MYD88(L265P) and CXCR4 mutations and underlying haemopathy.0
382204792024C-X-C motif chemokine receptor 4 inhibition promotes the effect of plantamajoside in hepatocellular carcinoma.0
383069532024CXCL12-CXCR4 mediates CD57(+) CD8(+) T cell responses in the progression of type 1 diabetes.2
383661012024CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study.0
384303372024Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala.0
384429082024CXCR4 WHIM syndrome is a cancer predisposition condition for virus-induced malignancies.0
384724462024Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.0
384875362024Intratumoral CXCR4(hi) neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma.0
385246302024Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms.0
385470612024The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells.1
385790482024The CXCR4 might be a potential biomarker for esophageal squamous cell carcinoma: A meta-analysis.0
387273182024Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.0

Citation

Dessen P

CXCR4 (C-X-C motif chemokine receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40225/deep-insight-explorer/gene-explorer/gene-explorer/