TET1 (tet methylcytosine dioxygenase 1)

2003-02-01  

Identity

HGNC
TET1
LOCATION
10q21.3
LOCUSID
80312
ALIAS
CXXC6,LCX,bA119F7.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80312
MIM: 607790
HGNC: 29484
Ensembl: ENSG00000138336

Variants:

dbSNP: 80312
ClinVar: 80312
TCGA: ENSG00000138336
COSMIC: TET1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138336ENST00000373644Q8NFU7

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
TET1,2,3 and TDG demethylate DNAREACTOMER-HSA-5221030

References

Pubmed IDYearTitleCitations
376102772024TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration.1
379959812024TET1 regulates stem cell properties and cell cycle of Cancer stem cells in triple-negative breast cancer via DNA demethylation.1
383697802024TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation.0
384318802024TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy.0
376102772024TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration.1
379959812024TET1 regulates stem cell properties and cell cycle of Cancer stem cells in triple-negative breast cancer via DNA demethylation.1
383697802024TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation.0
384318802024TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy.0
366827042023TET1-mediated microRNA-188-5p promoter hydroxymethylation regulates PTEN/PI3K/AKT signaling pathway in acute myeloid leukemia cells.0
366926702023High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications.0
370200362023Hypoxia switches TET1 from being tumor-suppressive to oncogenic.0
371217422023Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells.0
373472152023Functional polymorphisms of the TET1 gene increase the risk of neuroblastoma in Chinese children.5
374302062023MiR-183-5p promotes migration and invasion of prostate cancer by targeting TET1.1
374748472023Crosstalk between RNA m(6)A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells.3

Citation

Dessen P

TET1 (tet methylcytosine dioxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40227/meetings/haematological-explorer/deep-insight-explorer/