CYP1A1 (cytochrome P450 family 1 subfamily A member 1)

2003-02-01  

Identity

HGNC
CYP1A1
LOCATION
15q24.1
LOCUSID
1543
ALIAS
AHH,AHRR,CP11,CYP1,CYPIA1,P1-450,P450-C,P450DX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1543
MIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465

Variants:

dbSNP: 1543
ClinVar: 1543
TCGA: ENSG00000140465
COSMIC: CYP1A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140465ENST00000379727P04798
ENSG00000140465ENST00000379727A0N0X8
ENSG00000140465ENST00000395048P04798
ENSG00000140465ENST00000395048A0N0X8
ENSG00000140465ENST00000395049E7EMT5
ENSG00000140465ENST00000562201P04798
ENSG00000140465ENST00000564596P04798
ENSG00000140465ENST00000566503A4F3V8
ENSG00000140465ENST00000567032P04798
ENSG00000140465ENST00000567032A0N0X8
ENSG00000140465ENST00000569630P04798
ENSG00000140465ENST00000612821Q5J9B1
ENSG00000140465ENST00000617691E7EMT5

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Tryptophan metabolismKEGGko00380
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Steroid hormone biosynthesisKEGGhsa00140
Tryptophan metabolismKEGGhsa00380
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPK25348619, 27193993
PA166123431heart valve replacementDiseaseClinicalAnnotationassociatedPD27740732
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD22426923
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD21121773, 26951882
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPK25348619, 27193993
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPK23492908
PA448404amodiaquineChemicalPathwayassociated
PA448771capecitabineChemicalClinicalAnnotationassociatedPD22426923
PA448785carbamazepineChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA449197dacarbazineChemicalVariantAnnotationassociatedPK27428168
PA449383docetaxelChemicalClinicalAnnotationassociatedPD22426923
PA449563exemestaneChemicalVariantAnnotationnot associatedPK
PA449809granisetronChemicalClinicalAnnotation, VariantAnnotationassociatedPK27809336
PA450688olanzapineChemicalClinicalAnnotationassociatedPK23492908
PA450911phenobarbitalChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA450947phenytoinChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA451846valproic acidChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA451906warfarinChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD27740732, 8689941

References

Pubmed IDYearTitleCitations
366236732023Genic-intergenic polymorphisms of CYP1A genes and their clinical impact.1
368810572023Association Between CYP1A1 Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study.0
369212082023Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris.0
371950872023CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination.0
375069882023Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population.0
375112392023Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.1
383762982023Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study.1
366236732023Genic-intergenic polymorphisms of CYP1A genes and their clinical impact.1
368810572023Association Between CYP1A1 Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study.0
369212082023Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris.0
371950872023CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination.0
375069882023Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population.0
375112392023Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.1
383762982023Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study.1
353803342022Contribution of CYP19A1, CYP1A1, and CYP1A2 polymorphisms in coronary heart disease risk among the Chinese Han population.0

Citation

Dessen P

CYP1A1 (cytochrome P450 family 1 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40235