CYP1A2 (cytochrome P450 family 1 subfamily A member 2)

2003-06-01 Affiliation

Identity

HGNC

CYP1A2

LOCATION

15q24.1

LOCUSID

1544

ALIAS

CP12,CYPIA2,P3-450,P450(PA)

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1544
MIM: 124060
HGNC: 2596
Ensembl: ENSG00000140505

Variants:

dbSNP: 1544
ClinVar: 1544
TCGA: ENSG00000140505
COSMIC: CYP1A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140505	ENST00000343932	P05177

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Steroid hormone biosynthesis	KEGG	ko00140
Caffeine metabolism	KEGG	ko00232
Tryptophan metabolism	KEGG	ko00380
Linoleic acid metabolism	KEGG	ko00591
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Steroid hormone biosynthesis	KEGG	hsa00140
Caffeine metabolism	KEGG	hsa00232
Tryptophan metabolism	KEGG	hsa00380
Linoleic acid metabolism	KEGG	hsa00591
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	REACTOME	R-HSA-2142670
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	REACTOME	R-HSA-211957
Phase II conjugation	REACTOME	R-HSA-156580
Methylation	REACTOME	R-HSA-156581
Aflatoxin activation and detoxification	REACTOME	R-HSA-5423646

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10035	bromazepam	Chemical	Pathway	associated
PA10074	escitalopram	Chemical	ClinicalAnnotation	associated	PK	PD	23859573
PA10075	esomeprazole	Chemical	LabelAnnotation	associated
PA10804	imatinib	Chemical	ClinicalAnnotation	associated		PD	30713339
PA124	CYP2C19	Gene	DataAnnotation	associated
PA128	CYP2D6	Gene	DataAnnotation	associated
PA134687924	erlotinib	Chemical	ClinicalAnnotation	associated	PK		25408262
PA151958383	Gastrointestinal Stromal Tumors	Disease	ClinicalAnnotation	associated		PD	30713339
PA164746058	albendazole	Chemical	VipGene	associated			18502397
PA164746757	tolterodine	Chemical	LabelAnnotation	associated
PA164760843	deferasirox	Chemical	ClinicalAnnotation	associated	PK		25348619, 27193993
PA165946873	vemurafenib	Chemical	MultilinkAnnotation	associated			23116250
PA166048714	Pregnancy	Disease	VariantAnnotation	associated		PD	11755554
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166123307	insomnia	Disease	ClinicalAnnotation	associated		PD	29668752
PA166129521	sedation	Disease	VariantAnnotation	associated		PD	21481946
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166154850	rs762551	Variant	VipGene	associated			11496364, 11763009, 12920202, 15206669, 15505641, 16385402, 16490169, 16522833, 16905781, 17370067, 17611010, 17688403, 18075470, 18180754, 18466106, 19636338, 21121774, 10889552
PA166154874	rs2069514	Variant	VipGene	associated			12732846, 15505641, 15564895, 16385402, 20390257, 10101295
PA166154935	rs12720461	Variant	VipGene	associated			12920202
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA193	HTR2A	Gene	DataAnnotation	associated
PA312	SLC6A4	Gene	DataAnnotation	associated
PA443227	Abortion, Spontaneous	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	11755554, 15849225, 17370067
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation	associated	PK	PD	18496682, 19581389
PA443560	Breast Neoplasms	Disease	VariantAnnotation	not associated			17507615
PA443636	Carotid Artery Diseases	Disease	VariantAnnotation	not associated		PD	26526111
PA443771	Confusion	Disease	VariantAnnotation	associated		PD	21481946
PA443937	Drug Toxicity	Disease	VariantAnnotation	associated		PD	21481946
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK		26762380
PA444354	Headache	Disease	VariantAnnotation	associated		PD	21481946
PA444993	Muscle Rigidity	Disease	VariantAnnotation	associated		PD	21481946
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	16522833
PA445043	Opioid-Related Disorders	Disease	VariantAnnotation	not associated	PK		17178267
PA445629	Seizures	Disease	VariantAnnotation	associated		PD	23601795
PA445802	Tachycardia	Disease	VariantAnnotation	associated		PD	21481946
PA445876	Tobacco Use Disorder	Disease	VariantAnnotation, VipGene	associated	PK		17370067, 18687246
PA446432	beta-Thalassemia	Disease	ClinicalAnnotation	associated	PK		25348619, 27193993
PA447216	Schizophrenia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	15505641, 17611010, 18223460, 19000940, 21481946, 23601795
PA447278	Depression	Disease	DataAnnotation, VariantAnnotation	associated		PD	27800629
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation, DataAnnotation	associated	PK	PD	21121774, 21593735, 23859573
PA448015	acetaminophen	Chemical	Literature, MultilinkAnnotation, Pathway	associated			19219744, 26049587
PA448710	caffeine	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10101295, 10233211, 11755554, 12920202, 15849225, 16522833, 17370067, 17507615, 20390257, 21593735, 29282363, 29668752, 8491061, 8689941
PA448785	carbamazepine	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PK		26762380
PA448964	chlorpromazine	Chemical	ClinicalAnnotation	associated		PD	17611010
PA449048	clomipramine	Chemical	Pathway, VariantAnnotation	associated		PD	27800629
PA449053	clopidogrel	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	18687246, 20938371, 21148426, 24262617, 26526111
PA449061	clozapine	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	19593168, 20125119, 21481946, 23601795
PA449197	dacarbazine	Chemical	VariantAnnotation	associated	PK		27428168
PA449233	desipramine	Chemical	Pathway	associated
PA449409	doxepin	Chemical	Pathway	associated
PA449646	flecainide	Chemical	VariantAnnotation	associated	PK		22718623
PA449676	fluphenazine	Chemical	ClinicalAnnotation	associated		PD	17611010
PA449690	fluvoxamine	Chemical	MultilinkAnnotation, VipGene	associated			11763009, 8823236
PA449969	imipramine	Chemical	Pathway	associated
PA450180	lansoprazole	Chemical	VipGene	associated			18502397
PA450192	leflunomide	Chemical	ClinicalAnnotation	associated	PK	PD	18496682, 19581389
PA450401	methadone	Chemical	VariantAnnotation	not associated	PK		17178267
PA450688	olanzapine	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	18223460, 19000940, 19636338, 23492908
PA450704	omeprazole	Chemical	VipGene	associated			18502397
PA450801	paroxetine	Chemical	ClinicalAnnotation, Pathway, VipGene	associated	PK	PD	21121774, 21593735
PA451103	primaquine	Chemical	VipGene	associated			18502397
PA451201	quetiapine	Chemical	VariantAnnotation	associated	PK		25025989
PA451581	tamoxifen	Chemical	Pathway	associated			23962908
PA451647	theophylline	Chemical	Pathway, VipGene	associated			18466106
PA451666	thioridazine	Chemical	ClinicalAnnotation	associated		PD	17611010
PA451771	trifluoperazine	Chemical	ClinicalAnnotation	associated		PD	17611010
PA451906	warfarin	Chemical	MultilinkAnnotation, VipGene	associated			17392729, 8689941, 8723744
PA452233	antipsychotics	Chemical	ClinicalAnnotation, VipGene	associated		PD	19593168, 15505641, 17611010
PA452604	xenobiotics	Chemical	VariantAnnotation	associated	PK		12920202

References

Pubmed ID	Year	Title	Citations
37906419	2024	Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism.	0
37906419	2024	Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism.	0
36239290	2023	The influence of the CYP1A2-163 C>A polymorphism on the hemostatic response to exercise following caffeine supplementation.	0
36701157	2023	CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.	5
37511239	2023	Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.	1
36239290	2023	The influence of the CYP1A2-163 C>A polymorphism on the hemostatic response to exercise following caffeine supplementation.	0
36701157	2023	CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.	5
37511239	2023	Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.	1
34564706	2022	CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.	8
35338582	2022	Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.	1
35380334	2022	Contribution of CYP19A1, CYP1A1, and CYP1A2 polymorphisms in coronary heart disease risk among the Chinese Han population.	0
35905656	2022	Functional single-nucleotide polymorphism (rs762551) in CYP1A2 gene affects white coffee intake in healthy 20- to 40-year-old adults.	0
36011409	2022	Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR.	0
34564706	2022	CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.	8
35338582	2022	Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.	1

Citation

Dessen P

CYP1A2 (cytochrome P450 family 1 subfamily A member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40236/gene-explorer/haematological-explorer/