CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

2003-06-01 Affiliation

Identity

HGNC

CYP2B6

LOCATION

19q13.2

LOCUSID

1555

ALIAS

CPB6,CYP2B,CYP2B7,CYP2B7P,CYPIIB6,EFVM,IIB1,P450

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1555
MIM: 123930
HGNC: 2615
Ensembl: ENSG00000197408

Variants:

dbSNP: 1555
ClinVar: 1555
TCGA: ENSG00000197408
COSMIC: CYP2B6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197408	ENST00000324071	P20813
ENSG00000197408	ENST00000593831	M0QZJ2
ENSG00000197408	ENST00000598834	A0A2R8YFA4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Arachidonic acid metabolism	KEGG	hsa00590
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
CYP2E1 reactions	REACTOME	R-HSA-211999
Fatty acids	REACTOME	R-HSA-211935

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10804	imatinib	Chemical	ClinicalAnnotation	associated		PD	24293093
PA131887008	3,4-methylenedioxymethamphetamine	Chemical	ClinicalAnnotation, VipGene	associated	PK		17638512, 11470993, 28117133
PA134850491	Transplantation	Disease	ClinicalAnnotation	associated	PK	PD	19005482
PA154410481	prasugrel	Chemical	LabelAnnotation, Literature, MultilinkAnnotation	associated			21828263
PA164712505	Antivirals for treatment of HIV infections, combinations	Chemical	ClinicalAnnotation	associated		PD	22162992
PA164712708	Drugs For Treatment Of Tuberculosis	Chemical	ClinicalAnnotation	associated		PD	22162992
PA164746157	mitotane	Chemical	ClinicalAnnotation	associated	PK		23524664
PA164781343	varenicline	Chemical	MultilinkAnnotation, VariantAnnotation	ambiguous		PD	26153084, 31402421
PA164784021	ethambutol	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	28389387
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	21824325, 23774940, 24359841, 28689274
PA165111696	artemisinin	Chemical	Pathway, VipGene	associated			17638512, 11470993
PA165111698	artemether	Chemical	ClinicalAnnotation	associated	PK
PA165260403	arteether	Chemical	Pathway	associated
PA165818750	CYP2B6*1	Haplotype	LabelAnnotation	associated
PA165818757	CYP2B6*4	Haplotype	VipGene	associated			16272958, 16495778, 17235330, 12642465
PA165818762	CYP2B6*6	Haplotype	GuidelineAnnotation, LabelAnnotation, VipGene	associated			12629583, 12642465, 14551287, 15194512, 15622315, 15825040, 16272958, 16495778, 16912956, 16912957, 17235330, 17502835, 17918089, 18171905, 18839779, 19474465, 19531981, 11470993
PA165818765	CYP2B6*7	Haplotype	VipGene	associated			16272958, 16495778, 17235330, 12642465
PA165818780	CYP2B6*16	Haplotype	VipGene	associated			16272958, 16495778, 17235330, 15469410
PA165818808	CYP2B6*18	Haplotype	GuidelineAnnotation, VipGene	associated			16272958, 16495778, 17235330, 15469410
PA166048714	Pregnancy	Disease	VariantAnnotation	associated	PK
PA166114414	cotinine	Chemical	ClinicalAnnotation	associated	PK		18004205
PA166119041	drug-induced liver injury	Disease	VariantAnnotation	associated		PD	28389387
PA166120927	drug reaction with eosinophilia and systemic symptoms	Disease	ClinicalAnnotation	associated		PD	21824325, 23774940, 28689274
PA166123507	discontinuation	Disease	VariantAnnotation	associated		PD
PA166124406	platelet reactivity	Disease	VariantAnnotation	not associated		PD	27380588
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166155393	rs2279343	Variant	VipGene	associated			16272958, 16495778, 17235330, 12642465
PA166155405	rs3211371	Variant	VipGene	associated			12439223, 12814665, 14515060, 14551287, 15083067, 17638512, 11470993
PA166155409	rs3745274	Variant	LabelAnnotation, VipGene	associated			14551287, 15622315, 15825040, 16912956, 16912957, 17918089, 18171905, 18839779, 19474465, 19531981, 11470993
PA166155478	rs28399499	Variant	VipGene	associated			16272958, 16495778, 17235330, 15469410
PA166176033	efavirenz / emtricitabine / tenofovir disoproxil	Chemical	LabelAnnotation	associated
PA166178554	(S)-methadone	Chemical	VariantAnnotation	associated	PK		17178267
PA166182883	ospemifene	Chemical	LabelAnnotation	associated
PA378	NR1I2	Gene	Pathway	associated			21738081
PA391	NR1I3	Gene	Pathway	associated			21738081
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	18024866, 20179710, 24682508, 29938344
PA443636	Carotid Artery Diseases	Disease	VariantAnnotation	not associated		PD	26526111
PA443657	Central Nervous System Diseases	Disease	VariantAnnotation	associated		PD	17686225
PA443833	Cystitis	Disease	ClinicalAnnotation	associated	PK	PD	19005482
PA443842	Death	Disease	VariantAnnotation	not associated		PD
PA443937	Drug Toxicity	Disease	VariantAnnotation	ambiguous		PD	24128861
PA444059	Epidermal Necrolysis, Toxic	Disease	ClinicalAnnotation	associated		PD	23774940, 28689274
PA444434	Hepatic Veno-Occlusive Disease	Disease	ClinicalAnnotation	associated	PK	PD	19005482
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated	PK	PD	16338275, 17178267, 17329992, 17502774, 21790905, 21902500, 25556837, 27289271, 30907440
PA444807	Long QT Syndrome	Disease	VariantAnnotation	associated		PD
PA444819	Lupus erythematosus	Disease	ClinicalAnnotation	associated	PK	PD
PA444845	Lymphoma, Non-Hodgkin	Disease	VariantAnnotation	associated	PK		28181240
PA445019	Myocardial Infarction	Disease	VariantAnnotation	not associated		PD
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	16338275, 17178267, 17329992, 17502774, 27286724, 27289271
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK
PA445208	Pain	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	27289271
PA445506	Recurrence	Disease	VariantAnnotation	not associated		PD	18024866, 24682508
PA445738	Stevens-Johnson Syndrome	Disease	ClinicalAnnotation	associated		PD	21824325, 23774940, 28689274
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	12439223, 17015050, 17223085, 18004205, 26153084, 31402421
PA445941	Tuberculosis	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22162992, 24293076, 24477223, 27045425, 28389387
PA446169	Leukemia, Lymphocytic, Chronic, B-Cell	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	24128861
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	ClinicalAnnotation	associated		PD	24293093
PA446304	Lymphoma, B-Cell	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		26773420
PA446644	Adrenocortical Carcinoma	Disease	ClinicalAnnotation	associated	PK		23524664
PA446975	Neurotoxicity Syndromes	Disease	VariantAnnotation	ambiguous		PD	23640958
PA447230	HIV Infections	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	15194512, 15622315, 15864119, 16267764, 16272958, 16495778, 17235330, 17559344, 17686225, 17918089, 17968817, 19228205, 20017669, 20441246, 20625352, 20860463, 20881953, 20952418, 21505298, 21715435, 21814190, 21821736, 21824325, 21860339, 21862974, 22057858, 22162992, 22354160, 23089673, 23172109, 23399569, 23640958, 23774940, 23778320, 23859571, 23970651, 23996099, 24080498, 24293076, 24316028, 24359841, 24477223, 24517233, 24831655, 24956253, 25303294, 25669165, 26196596, 26774523, 26779253, 27045425, 28622951, 28689274, 28886044, 29624706, 31628422
PA447278	Depression	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22926595
PA447321	Depressive Disorder, Major	Disease	VariantAnnotation	associated	PK		26830411
PA448687	bupropion	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	17638512, 11470993, 12439223, 14515060, 15083067, 15722458, 17223085, 26153084, 26580670, 28181240, 29756345
PA448691	busulfan	Chemical	VariantAnnotation	associated		PD	24165757
PA448785	carbamazepine	Chemical	Pathway, VipGene	associated			17638512, 21738081
PA448926	chlorambucil	Chemical	VariantAnnotation	not associated		PD	24128861
PA449053	clopidogrel	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous		PD	17638512, 20938371, 21828263, 21831410, 26526111, 27380588, 28135763
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	17638512, 11470993, 19005482, 20179710, 21821736, 24128861, 26773420, 28181240, 29938344
PA449283	diazepam	Chemical	VipGene	associated			17638512, 11470993
PA449412	doxorubicin	Chemical	ClinicalAnnotation	associated		PD	20179710, 29938344
PA449441	efavirenz	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	17638512, 11470993, 15194512, 15622315, 15864119, 16267764, 16495778, 17235330, 17559344, 17686225, 17918089, 17968817, 20441246, 20625352, 20860463, 20881953, 20952418, 21715435, 21814190, 21821736, 21862974, 22057858, 23089673, 23172109, 23399569, 23640958, 23778320, 23859571, 23970651, 23990572, 23996099, 24080498, 24293076, 24316028, 24359841, 24477223, 24497997, 24517233, 24729586, 24831655, 24956253, 25303294, 25669165, 26196596, 26604812, 26622191, 26774523, 26779253, 26831894, 26991336, 27045425, 28622951, 28886044, 29624706, 31628422
PA449527	ethinyl estradiol	Chemical	VipGene	associated			17638512
PA449655	fludarabine	Chemical	VariantAnnotation	ambiguous		PD	24128861
PA449964	ifosfamide	Chemical	VipGene	associated			17638512, 11470993
PA450112	isoniazid	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	28389387
PA450144	ketamine	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	associated	PK		17638512, 11470993, 25702819
PA450163	lamivudine	Chemical	VariantAnnotation	associated	PK		23089673
PA450369	meperidine	Chemical	VipGene	associated			17638512, 11470993
PA450373	mephenytoin	Chemical	VipGene	associated			17638512, 11470993
PA450401	methadone	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	associated	PK	PD	17638512, 11470993, 16338275, 17178267, 17329992, 17502774, 21790905, 21902500, 23249875, 25556837, 27286724, 27289271, 30907440
PA450496	midazolam	Chemical	VipGene	associated			17638512, 11470993
PA450522	mirtazapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22926595
PA450616	nevirapine	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	17638512, 11470993, 15864119, 16272958, 16495778, 19228205, 20017669, 20625352, 21505298, 21824325, 21860339, 22354160, 23774940, 28689274
PA450626	nicotine	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	associated	PK	PD	17638512, 11470993, 17015050, 18004205, 25652250
PA450911	phenobarbital	Chemical	VipGene	associated			17638512
PA450947	phenytoin	Chemical	VipGene	associated			17638512
PA451141	propofol	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	17638512, 11470993, 22006347, 26141406, 28154789
PA451182	pyrazinamide	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	28389387
PA451250	rifampin	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	associated		PD	17638512, 27053325, 28389387
PA451316	selegiline	Chemical	VipGene	associated			17638512, 11470993
PA451333	sertraline	Chemical	VariantAnnotation	associated	PK		26830411
PA451344	sibutramine	Chemical	VariantAnnotation	not associated	PK		23381968
PA451494	stavudine	Chemical	VariantAnnotation	associated	PK		23089673
PA451581	tamoxifen	Chemical	Pathway, VariantAnnotation, VipGene	ambiguous		PD	17638512, 11470993, 18024866, 23962908, 24682508
PA451668	thiotepa	Chemical	VipGene	associated			17638512
PA451686	ticlopidine	Chemical	VipGene	associated			17638512
PA451735	tramadol	Chemical	Pathway	associated			24849324
PA451954	zidovudine	Chemical	VariantAnnotation	associated	PK		23089673
PA452609	aflatoxin b1	Chemical	VipGene	associated			17638512, 11470993
PA452621	antineoplastic agents	Chemical	VariantAnnotation	not associated		PD	24682508
PA7000	sorafenib	Chemical	Pathway	associated			28362716

References

Pubmed ID	Year	Title	Citations
38071562	2024	Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.	0
38560574	2024	The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.	0
38071562	2024	Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.	0
38560574	2024	The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.	0
36418184	2023	Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.	1
36817260	2023	Allelic and Genotype Frequencies of CYP2B6(∗)2 (64C > T) and CYP2B6(∗)3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.	0
37078251	2023	Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.	1
37512019	2023	Expression of CYP2B6 Enzyme in Human Liver Tissue of HIV and HCV Patients.	1
37995809	2023	Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.	0
38166557	2023	Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.	1
36418184	2023	Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.	1
36817260	2023	Allelic and Genotype Frequencies of CYP2B6(∗)2 (64C > T) and CYP2B6(∗)3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.	0
37078251	2023	Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.	1
37512019	2023	Expression of CYP2B6 Enzyme in Human Liver Tissue of HIV and HCV Patients.	1
37995809	2023	Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.	0

Citation

Dessen P

CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40241/haematological-explorer/js/meetings/