CYP2D6 (cytochrome P450 family 2 subfamily D member 6)

2003-08-01 Affiliation

Identity

HGNC

CYP2D6

LOCATION

22q13.2

LOCUSID

1565

ALIAS

CPD6,CYP2D,CYP2D7AP,CYP2D7BP,CYP2D7P2,CYP2D8P2,CYP2DL1,CYPIID6,P450-DB1,P450C2D,P450DB1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1565
MIM: 124030
HGNC: 2625
Ensembl: ENSG00000100197

Variants:

dbSNP: 1565
ClinVar: 1565
TCGA: ENSG00000100197
COSMIC: CYP2D6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100197	ENST00000359033	P10635
ENSG00000100197	ENST00000360124	H7BY38
ENSG00000100197	ENST00000389970	E7ENE7
ENSG00000100197	ENST00000645361	P10635
ENSG00000100197	ENST00000645361	C1ID52

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Serotonergic synapse	KEGG	hsa04726
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
CYP2E1 reactions	REACTOME	R-HSA-211999
Fatty acids	REACTOME	R-HSA-211935
Miscellaneous substrates	REACTOME	R-HSA-211958
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10026	aripiprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	17828532, 17965519, 21739267, 24232129, 26514968, 29472872
PA10035	bromazepam	Chemical	Pathway	associated
PA10066	duloxetine	Chemical	GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	17713974, 23545896
PA10074	escitalopram	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	11802100, 12968986, 18070221, 18382661, 19840783, 20350136, 21192344, 21926427, 22775532, 23545896, 23981149, 24014145, 8451774, 8835706
PA10075	esomeprazole	Chemical	LabelAnnotation	associated
PA10268	flupenthixol	Chemical	GuidelineAnnotation	associated
PA10284	oxprenolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA10352	palonosetron	Chemical	LabelAnnotation	associated
PA124	CYP2C19	Gene	DataAnnotation	associated
PA128406954	Weight gain	Disease	VariantAnnotation	ambiguous		PD	11901361, 23289191
PA130150436	perhexiline	Chemical	VipGene	associated
PA130620651	anthracyclines and related substances	Chemical	VariantAnnotation	ambiguous		PD	20849243
PA131301952	gefitinib	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	15788367, 16719544, 21502555, 23664723, 25554506, 26323212, 26898617
PA131887008	3,4-methylenedioxymethamphetamine	Chemical	VariantAnnotation	associated	PK	PD
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134687907	formoterol	Chemical	LabelAnnotation	associated
PA134687924	erlotinib	Chemical	VariantAnnotation	not associated		PD
PA134687937	mianserin	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	14652703, 1527229, 8062494, 9408809
PA134687942	levomepromazine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	19308365, 29472872
PA134687947	eletriptan	Chemical	LabelAnnotation	associated
PA134688071	atomoxetine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	11854152, 12485958, 17224704, 17242628, 17470523, 17698328, 19387424, 20691935, 21543662, 25919121, 26254792, 26666748
PA140222719	tetrabenazine	Chemical	LabelAnnotation, VariantAnnotation	associated		PD	23280482
PA144614922	opipramol	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD
PA151958426	nebivolol	Chemical	LabelAnnotation	associated
PA153619853	dronedarone	Chemical	LabelAnnotation	associated
PA161199368	iloperidone	Chemical	ClinicalAnnotation, LabelAnnotation	associated		PD	23277250
PA161925594	tropisetron	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	associated	PK	PD	12065557, 12728290
PA163518919	paliperidone	Chemical	LabelAnnotation	associated
PA164712732	Enzyme inhibitors	Chemical	VariantAnnotation	not associated		PD
PA164712951	Opium derivatives and expectorants	Chemical	LabelAnnotation	associated
PA164713257	Selective serotonin reuptake inhibitors	Chemical	MultilinkAnnotation	associated			26871771
PA164743150	labetalol	Chemical	VariantAnnotation	not associated		PD	18784654
PA164743236	bevantolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA164743977	arformoterol	Chemical	LabelAnnotation	associated
PA164744510	lofexidine	Chemical	LabelAnnotation	associated
PA164746007	ranolazine	Chemical	LabelAnnotation	associated
PA164746757	tolterodine	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PK	PD	10190648, 10583026, 20530222, 21352267, 28087463, 9630826
PA164749474	penbutolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA164754754	cevimeline	Chemical	LabelAnnotation	associated
PA164754755	bepridil	Chemical	VariantAnnotation	associated	PK		16508157
PA164769056	tiotropium	Chemical	LabelAnnotation	associated
PA164774901	darifenacin	Chemical	LabelAnnotation	associated
PA164784002	sertindole	Chemical	LabelAnnotation	associated
PA164924561	Celiprolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA164925725	Toxic liver disease	Disease	VariantAnnotation	ambiguous		PD	21502555, 23664723, 26323212
PA165108929	Binge eating disorder	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	29472872
PA165374639	suicide	Disease	VariantAnnotation	ambiguous			19907421, 27463022
PA165816576	CYP2D6*1	Haplotype	VipGene	associated			17301689, 11972444
PA165816577	CYP2D6*2	Haplotype	VipGene	associated			11972444, 10634130
PA165816578	CYP2D6*3	Haplotype	VipGene	associated			17301689, 2211621, 11972444
PA165816579	CYP2D6*4	Haplotype	VipGene	associated			16968950, 17301689, 1978251, 2211621, 9352573, 16958828
PA165816581	CYP2D6*6	Haplotype	VipGene	associated			17301689, 7951238, 11972444
PA165816582	CYP2D6*10	Haplotype	VipGene	associated			14618296, 17301689, 17570739, 8287064, 11972444
PA165816583	CYP2D6*17	Haplotype	VipGene	associated			9415713
PA165816584	CYP2D6*41	Haplotype	VipGene	associated			15289790, 11037799
PA165860812	berberine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		27023460
PA165946747	hydroxyamitriptyline	Chemical	VariantAnnotation	associated	PK
PA165948092	CYP2D6*5	Haplotype	VipGene	associated			8634695, 17301689
PA165948317	CYP2D6*9	Haplotype	VipGene	associated			17301689, 1844820, 8101460, 11972444
PA165948318	CYP2D6*29	Haplotype	VipGene	associated			17301689, 9241659, 11470994
PA165958374	desvenlafaxine	Chemical	LabelAnnotation, VariantAnnotation	associated	PK		29327975
PA165958376	fesoterodine	Chemical	LabelAnnotation	associated
PA166048829	Elderly Adult	Disease	VariantAnnotation	associated	PK		24858822
PA166110256	bufuralol	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		11470994, 11950793, 12152006, 17470523, 1844820, 18784265, 19158312, 2211621, 24647041, 25469868, 26310775, 27043475, 7935325, 8946471, 9089660, 9415713
PA166115462	dry mouth	Disease	VariantAnnotation	associated		PD	25919121
PA166115580	tafenoquine	Chemical	VariantAnnotation	not associated		PD
PA166121346	ibrutinib	Chemical	LabelAnnotation	associated
PA166122595	vortioxetine	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK
PA166123026	progression-free survival	Disease	VariantAnnotation	ambiguous		PD	15952058, 20849243
PA166123207	overall survival	Disease	VariantAnnotation	ambiguous		PD	15952058, 16361630, 17115111, 18024866, 18794105, 19596663, 23712329
PA166123306	agitation	Disease	VariantAnnotation	associated		PD
PA166123307	insomnia	Disease	VariantAnnotation	associated		PD	25919121
PA166123366	event-free survival	Disease	VariantAnnotation	ambiguous		PD	16361630, 17115111, 18024866, 18407954, 19189210, 19596663, 23167378, 23712329, 23842856, 24125101, 25211580
PA166123369	electrocardiogram qt prolonged	Disease	VariantAnnotation	not associated		PD	24589909
PA166123486	eliglustat	Chemical	GuidelineAnnotation, LabelAnnotation, MultilinkAnnotation	associated			20864621
PA166123507	discontinuation	Disease	VariantAnnotation	associated		PD	22733128
PA166124478	endoxifen	Chemical	VariantAnnotation	ambiguous	PK		14652237, 15632378, 16815318, 17761971, 26847054, 29436156
PA166127651	n-desmethyltamoxifen	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		15632378, 16815318, 17761971, 18838503, 24647041, 29436156
PA166127652	4-hydroxytamoxifen	Chemical	VariantAnnotation	ambiguous	PK		15632378, 17761971, 18407954, 29436156
PA166127658	Recurrence free survival	Disease	VariantAnnotation	ambiguous		PD	16361630, 17115111, 19156902, 20574415, 20809362, 21437611
PA166128121	cardiotoxicity	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	21691803, 8422746
PA166129521	sedation	Disease	VariantAnnotation	associated		PD	14646691
PA166131379	o-desmethyltramadol	Chemical	VariantAnnotation	associated	PK		27082504
PA166131507	desmethyl clomipramine	Chemical	VariantAnnotation	associated	PK		28470111
PA166131548	noroxymorphone	Chemical	VariantAnnotation	associated	PK
PA166151827	adverse events	Disease	VariantAnnotation	ambiguous		PD	15669884, 27469576, 31107373
PA166151992	dapoxetine	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK		26937172
PA166152940	tolperisone	Chemical	ClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK		25953735
PA166153416	coptisine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK		27023460
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166156031	rs16947	Variant	VipGene	associated			11972444, 16835697, 10634130
PA166156062	rs1065852	Variant	VipGene	associated			12386125, 16490169, 16835697, 2211621, 10634130
PA166156104	rs3892097	Variant	VipGene	associated			1978251, 2211621, 9241659, 9895131, 10634130
PA166156111	rs5030655	Variant	VipGene	associated			7868129, 7894499, 7951238, 10634130
PA166156112	rs5030656	Variant	VipGene	associated			1844820, 8101460, 10634130
PA166156151	rs28371706	Variant	VipGene	associated			9415713
PA166156155	rs28371725	Variant	VipGene	associated			17001295, 17112815, 15289790
PA166156167	rs35742686	Variant	VipGene	associated			2211621, 9241659, 10634130
PA166156171	rs59421388	Variant	VipGene	associated			11470994, 9241659, 11407994
PA166156172	rs61736512	Variant	VipGene	associated			9241659, 11470994
PA166160053	brexpiprazole	Chemical	GuidelineAnnotation, LabelAnnotation	associated
PA166161216	aripiprazole lauroxil	Chemical	LabelAnnotation	associated
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166169881	deutetrabenazine	Chemical	LabelAnnotation	associated
PA166170051	valbenazine	Chemical	LabelAnnotation	associated
PA166170367	extrapyramidal symptoms	Disease	VariantAnnotation	ambiguous		PD	12960748, 16478753, 27469576
PA166170669	cns depression in infants	Disease	VariantAnnotation	not associated		PD	23783165
PA166175998	dextromethorphan / quinidine	Chemical	LabelAnnotation	associated
PA166176027	fluoxetine / olanzapine	Chemical	LabelAnnotation	associated
PA166176885	dihydrocodeine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	29389842
PA166177476	cariprazine	Chemical	LabelAnnotation	associated
PA166177513	mirabegron	Chemical	LabelAnnotation	associated
PA166177519	umeclidinium	Chemical	LabelAnnotation	associated
PA166177880	hepatic cytolysis	Disease	VariantAnnotation	associated
PA166184061	acetaminophen / codeine	Chemical	LabelAnnotation	associated
PA166184233	vernakalant	Chemical	LabelAnnotation	associated
PA166184235	umeclidinium / vilanterol	Chemical	LabelAnnotation	associated
PA166184497	Paracetamol, combinations excl. Psycholeptics (Vicks MediNait Sirup)	Chemical	LabelAnnotation	associated
PA166185163	pitolisant	Chemical	LabelAnnotation	associated
PA166189803	upadacitinib	Chemical	LabelAnnotation	associated
PA166210801	ethylmorphine	Chemical	ClinicalAnnotation	associated	PK
PA193	HTR2A	Gene	DataAnnotation	associated
PA27093	CYP1A2	Gene	DataAnnotation	associated
PA312	SLC6A4	Gene	DataAnnotation	associated
PA443265	Adenocarcinoma	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	16719544, 21502555, 23664723, 25554506, 26323212, 26898617
PA443319	Alzheimer Disease	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	26952092
PA443355	Anemia, Sickle Cell	Disease	VariantAnnotation	associated	PK
PA443362	Angina Pectoris	Disease	VariantAnnotation	ambiguous	PK		16849011
PA443421	Arrhythmias, Cardiac	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	12421483, 14653957, 16508157, 16944116, 22718623, 22941032
PA443472	Back Pain	Disease	VariantAnnotation	associated	PK	PD	19308365
PA443548	Bradycardia	Disease	VariantAnnotation	ambiguous		PD	18784654
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	14652237, 15632378, 15952058, 16361630, 16815318, 16877740, 17115111, 17761971, 18024866, 18294285, 18407954, 18794105, 19156902, 19189210, 19189212, 19596663, 20309015, 20454926, 20515869, 20574415, 20809362, 20849243, 21437611, 21451508, 21823108, 21830868, 21947681, 22180457, 22623212, 23100173, 23167378, 23289191, 23570465, 23712329, 23842856, 24062210, 24125101, 24265036, 24329190, 24647041, 24682508, 24685597, 24744093, 25211580, 26192892, 26681084, 26847054, 27109434, 27484880, 27797974, 29436156, 30022682
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16719544, 21502555, 23664723, 25554506, 26323212, 26898617
PA443782	Constipation	Disease	VariantAnnotation	associated		PD
PA443842	Death	Disease	VariantAnnotation	ambiguous	PK	PD	19189212, 22492761, 23570465
PA443853	Dementia	Disease	ClinicalAnnotation	associated	PK		23503455
PA443899	Diarrhea	Disease	ClinicalAnnotation	associated	PK	PD	16642541, 16958828
PA443928	Dizziness	Disease	VariantAnnotation	associated		PD
PA443937	Drug Toxicity	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12920424, 15590749, 16642541, 16871470, 16958828, 19189210, 20691935, 25554506, 6111662, 8941025
PA443970	Dystonia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10579557, 11214775, 12629505, 12960748, 15118351, 15861039, 16478753, 20877299, 9068770, 9201806, 9713905, 9713906
PA444065	Epilepsy	Disease	VariantAnnotation	associated	PK		24915025
PA444109	Exanthema	Disease	VariantAnnotation	associated		PD
PA444239	Galactorrhea	Disease	VariantAnnotation	associated
PA444368	Heart Diseases	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		16595916, 17329852
PA444370	Heart Failure	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	20643254
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated	PK	PD	11270921, 17234366, 29333880, 30907440
PA444524	Hyperhidrosis	Disease	VariantAnnotation	associated		PD	25919121
PA444545	Hyperprolactinemia	Disease	VariantAnnotation	not associated		PD	26872113
PA444552	Hypertension	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10471072, 11692084, 11823760, 15467211, 15592325, 15726636, 18834373, 24193112
PA444606	Erectile Dysfunction	Disease	VariantAnnotation	associated		PD	25919121
PA444859	Malaria	Disease	VariantAnnotation	ambiguous	PK	PD	24088113
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11270921, 17234366, 17725248, 29333880, 30907440, 9352573
PA445048	Nausea	Disease	ClinicalAnnotation	associated	PK	PD	16642541, 16958828
PA445062	Neoplasms	Disease	VariantAnnotation	ambiguous		PD	12065557, 21840870
PA445208	Pain	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10850391, 11207001, 12422998, 12438554, 12920424, 14499440, 15625333, 16129989, 16631290, 16819548, 16920476, 16960721, 17361124, 17470523, 17725248, 17986163, 18204346, 18334103, 18520597, 18713907, 18719619, 19281600, 19308365, 19395173, 19514130, 19692698, 19719813, 19755414, 19940985, 21743374, 22398969, 22428763, 22492761, 23783165, 24077935, 24122716, 24747667, 25948472, 27082504, 30784356, 8803381, 8823235, 8988065, 9129563, 9357098, 9357099, 9415713
PA445210	Pain, Postoperative	Disease	VariantAnnotation	associated		PD	19523031
PA445293	Familial Mediterranean Fever	Disease	VariantAnnotation	associated		PD	25645282
PA445371	Poisoning	Disease	VariantAnnotation	associated	PK	PD	17721180, 18359183
PA445452	Psychomotor Agitation	Disease	VariantAnnotation	associated
PA445506	Recurrence	Disease	VariantAnnotation	ambiguous		PD	18024866, 18294285, 18794105, 20515869, 21823108, 22180457, 22623212, 23570465, 24682508, 30022682
PA445522	Respiratory Insufficiency	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	18713907, 25647677
PA445876	Tobacco Use Disorder	Disease	VariantAnnotation	associated		PD	26287939
PA446051	Vomiting	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12065557, 16551910, 16642541, 16958828
PA446264	Urinary Retention	Disease	VariantAnnotation	associated		PD	25919121
PA446852	Hot Flashes	Disease	VariantAnnotation	ambiguous		PD	16361630, 22623212, 23289191, 24265036
PA446876	Substance-Related Disorders	Disease	VariantAnnotation	not associated			27463022
PA446970	Postoperative Nausea and Vomiting	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	16551910
PA447194	Agoraphobia	Disease	VariantAnnotation	associated	PK	PD	8093319
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	10831022, 11854152, 12485958, 17224704, 17242628, 17470523, 17698328, 19387424, 20691935, 21543662, 23526481, 25919121, 26254792
PA447198	Autistic Disorder	Disease	VariantAnnotation	associated	PK		26780783
PA447207	Depressive Disorder	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10668847, 10774634, 10780263, 10877013, 11791895, 12544511, 12610741, 12682708, 12883230, 14652703, 16044105, 16205777, 16642541, 16958828, 17008819, 17803873, 18070221, 18214456, 18609433, 18978520, 19822698, 20118554, 20547595, 20807074, 22775532, 23332809, 23357843, 23545896, 24014145, 24663076, 24858822, 8823236, 9174682, 9517369
PA447208	Mental Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10208643, 10434486, 10505591, 10583026, 10668847, 10755579, 10824636, 10895986, 11386497, 11401659, 11417443, 11763000, 11791895, 12057035, 12172336, 12173784, 12352271, 12404686, 12438554, 12610741, 12682708, 12870705, 12883230, 1346258, 14514498, 14639062, 14652703, 14716707, 14726986, 15115913, 15205367, 1531950, 1531951, 15349705, 15367050, 15544025, 15570195, 15590749, 16024198, 16205777, 16236141, 16319918, 16423440, 16534507, 16633156, 16669849, 17008819, 17256449, 17470523, 17541852, 17764479, 18070221, 18359183, 18609433, 18641553, 18677622, 18978520, 19071885, 19743889, 20075642, 20118554, 20174590, 20531370, 20547595, 20807074, 21614669, 22733128, 22775532, 23437966, 23545896, 24663076, 24868171, 3356084, 3571939, 3769385, 6488689, 8422746, 8823236, 8941024, 9049581, 9174682, 9429230, 9517369
PA447209	Mood Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10208643, 10583026, 10755579, 11386497, 12172336, 12173784, 12404686, 12438554, 14639062, 14652703, 14716707, 14726986, 15205367, 15590749, 16024198, 16236141, 17008819, 17470523, 17764479, 18070221, 18359183, 20531370, 21614669, 22733128, 22775532, 23545896, 24663076, 27463022, 3571939, 8941024
PA447211	Obsessive-Compulsive Disorder	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10208643, 10434486, 10460069, 10505591, 10583026, 10668847, 10755579, 10774634, 10780263, 10824636, 10877013, 11386497, 11401659, 11763000, 11791895, 12057035, 12173784, 12352271, 12404686, 12438554, 12544511, 12610741, 12682708, 12870705, 12883230, 14514498, 1451721, 14639062, 14652703, 14716707, 14726986, 15252821, 1527229, 1531950, 1531951, 15349705, 15367050, 15544025, 15570195, 16044105, 16205777, 16236141, 16319918, 16423440, 16534507, 16633156, 16669849, 16871470, 16958828, 17008819, 17256449, 17470523, 17541852, 17803873, 18070221, 18214456, 18609433, 18641553, 18978520, 19743889, 19822698, 20075642, 20118554, 20174590, 20531370, 20547595, 20807074, 22733128, 22775532, 23332809, 23357843, 23437966, 23545896, 24014145, 24663076, 24858822, 24868171, 2741190, 3582462, 8093319, 8181196, 8823236, 8941024, 9174682, 9517369, 9562213
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10639689, 11791898, 15260906, 15565299, 15729081, 16633140, 16833023, 17715206, 20332423, 20814331, 22592207, 22775532, 23609392, 24026091, 24232129, 24329187, 24589909, 24643635, 24828442, 25042870, 26129906, 26514968, 26780783, 26944100, 27463022, 28389049, 30870237
PA447216	Schizophrenia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10096261, 10579557, 10639689, 10942177, 11041319, 11214775, 11560558, 11595402, 11699614, 11791898, 11901361, 12107620, 12640212, 12746736, 12784098, 12919180, 12960748, 14499311, 15118351, 15260906, 15565299, 15729081, 15861039, 16478753, 16633140, 16833023, 17503978, 17667795, 17715206, 18223460, 19000940, 20332423, 20814331, 22592207, 22775532, 23277250, 23609392, 24026091, 24232129, 24329187, 24589909, 24643635, 24828442, 25042870, 26129906, 26514968, 26780783, 26872113, 26944100, 27932669, 28389049, 29472872, 30870237, 9352580, 9713905, 9713906
PA447230	HIV	Disease	ClinicalAnnotation	associated	PK	PD
PA447268	tardive dyskinesia	Disease	VariantAnnotation	ambiguous		PD	10579557, 12960748, 15118351, 15861039, 16160620, 9713905, 9713906
PA447278	Depression	Disease	ClinicalAnnotation, DataAnnotation, VariantAnnotation	ambiguous	PK	PD	10460069, 11682257, 12360109, 12682708, 12883230, 1346258, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 1527229, 16024198, 16361630, 16642541, 16871470, 16958828, 17008819, 17667959, 17721180, 18359183, 20531370, 22926595, 28480819, 8181196, 8867869, 8941025, 9408809, 9562213, 9585799, 9918137
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation, DataAnnotation, VariantAnnotation	ambiguous	PK	PD	10208643, 10434486, 10460069, 10505591, 10583026, 10668847, 10755579, 10770451, 10774634, 10780263, 10824636, 11386497, 11401659, 11673748, 11682257, 11763000, 11791895, 11802100, 12057035, 12172336, 12173784, 12352271, 12404686, 12438554, 12610741, 12682708, 12814461, 12870705, 12883230, 12968986, 14514498, 1451721, 14639062, 14652703, 14716707, 14726986, 15116051, 15205367, 15252821, 1527229, 1531950, 1531951, 15349705, 15367050, 15483356, 15544025, 15570195, 15590749, 16024198, 16205777, 16236141, 16319918, 16423440, 16534507, 16633156, 16642541, 16669849, 16778723, 16871470, 16958828, 17008819, 17256449, 17470523, 17541852, 17667959, 17764479, 17803873, 18070221, 18214456, 18359183, 18382661, 18609433, 18641553, 18978520, 19743889, 19840783, 20075642, 20118554, 20174590, 20350136, 20531370, 20547595, 20807074, 21192344, 21614669, 21926427, 22389859, 22733128, 22775532, 2293406, 23437966, 23545896, 23799451, 23981149, 24014145, 24257813, 24663076, 24868171, 25761838, 2741190, 3356084, 3533565, 3571939, 3582462, 3769385, 4082245, 6111662, 7640151, 7965806, 8093319, 8181196, 8451774, 8823236, 8835706, 8867869, 8941024, 9174682, 9517369, 9562213, 9585799, 9797795
PA448011	acebutolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA448015	acetaminophen	Chemical	Literature, MultilinkAnnotation, Pathway, VariantAnnotation	associated	PK	PD	11095574, 17564651, 19219744, 19308365, 26049587
PA448073	ethanol	Chemical	Literature, MultilinkAnnotation	associated			24611668
PA448383	amiodarone	Chemical	GuidelineAnnotation	associated
PA448385	amitriptyline	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10460069, 11682257, 12172336, 12360109, 1346258, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 15590749, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 17764479, 18070221, 18359183, 20531370, 21614669, 22733128, 23486447, 27097346, 3571939, 3956053, 8181196, 8867869, 8941025, 9585799, 9918137
PA448405	amoxapine	Chemical	LabelAnnotation	associated
PA448408	amphetamine	Chemical	LabelAnnotation	associated
PA448497	aspirin	Chemical	ClinicalAnnotation	associated		PD
PA448499	atenolol	Chemical	GuidelineAnnotation, VariantAnnotation	ambiguous		PD	18784654
PA448500	atorvastatin	Chemical	Pathway, VariantAnnotation	associated		PD	17700359
PA448641	bisoprolol	Chemical	GuidelineAnnotation, VariantAnnotation	ambiguous		PD	18784654
PA448817	carvedilol	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	16595916, 16849011, 17329852, 20643254, 21599570, 7768074
PA448871	celecoxib	Chemical	Pathway, VariantAnnotation	ambiguous	PK		22336956, 26360837
PA448960	chlorpheniramine	Chemical	VipGene	associated
PA448964	chlorpromazine	Chemical	VipGene	associated			8739822
PA449009	ciprofloxacin	Chemical	VariantAnnotation	associated		PD	27469576
PA449015	citalopram	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	11802100, 12968986, 14652703, 18070221, 18382661, 19840783, 20350136, 21192344, 21546862, 21926427, 22775532, 23545896, 23981149, 24014145, 8451774, 8835706, 9110356
PA449048	clomipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10460069, 11682257, 11763000, 12360109, 1346258, 1451721, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 1527229, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18359183, 20531370, 23486447, 23545896, 2741190, 28470111, 29894392, 3582462, 8093319, 8181196, 8867869, 8941025, 9562213, 9585799, 9918137
PA449051	clonidine	Chemical	GuidelineAnnotation	associated
PA449061	clozapine	Chemical	GuidelineAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK		11041319, 17503978, 22722500, 23297297, 27932669
PA449088	codeine	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10850391, 11823760, 12438554, 12920424, 15625333, 16631290, 16819548, 16920476, 17470523, 17564651, 1782973, 18334103, 18713907, 18719619, 18838503, 19308365, 19395173, 19692698, 19940985, 21743374, 22205192, 22398969, 22492761, 24077935, 24122716, 24458010, 24479687, 24647041, 24747667, 25562725, 26984558, 27335380, 8823235, 9129563, 9352573, 9357098, 9357099, 9415713
PA449092	colchicine	Chemical	VariantAnnotation	associated		PD	25645282
PA449233	desipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	10460069, 10895986, 11417443, 11682257, 12360109, 1346258, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18359183, 20531370, 23486447, 27440861, 3356084, 3533565, 3769385, 6488689, 8181196, 8422746, 8867869, 8941025, 9049581, 9585799, 9918137
PA449273	dextromethorphan	Chemical	ClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10340923, 10471060, 11470994, 11692084, 11823760, 11950793, 12152006, 12438554, 12811367, 15149890, 15592325, 15618746, 15726636, 16283274, 16415111, 16679388, 17392730, 17470523, 18359183, 18784265, 18797858, 18838503, 19158312, 19364831, 20473659, 20881950, 23394389, 24647041, 25469868, 26310775, 26952092, 27023460, 27043475, 27339126, 28290770, 7935325, 8554938, 8807669, 8946471, 9089660, 9241659, 9415713
PA449373	disopyramide	Chemical	GuidelineAnnotation	associated
PA449390	dolasetron	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation	ambiguous		PD	16551910
PA449394	donepezil	Chemical	ClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PK	PD	24433464, 26952092
PA449409	doxepin	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10460069, 11037801, 11682257, 12360109, 1346258, 14520122, 14646691, 14716707, 15115913, 15205367, 15252821, 1527229, 16007002, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18359183, 20531370, 22999230, 23486447, 8181196, 8867869, 9585799, 9918137
PA449599	fentanyl	Chemical	ClinicalAnnotation	associated	PK	PD	25825958
PA449646	flecainide	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGene	ambiguous	PK		16944116, 22718623, 22941032, 2498026
PA449673	fluoxetine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10208643, 10583026, 10755579, 11386497, 12173784, 12404686, 12438554, 14639062, 14652703, 14716707, 14726986, 16236141, 17470523, 18070221, 22733128, 22775532, 23545896, 24663076, 8941024, 8941025
PA449676	fluphenazine	Chemical	GuidelineAnnotation	associated
PA449688	fluvastatin	Chemical	Pathway	associated
PA449690	fluvoxamine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10668847, 11791895, 12610741, 12682708, 12883230, 14652703, 16205777, 17484519, 18070221, 18609433, 18978520, 20118554, 20547595, 20807074, 22775532, 23545896, 25974703, 8823236, 9174682, 9517369
PA449726	galantamine	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK		23503455
PA449809	granisetron	Chemical	ClinicalAnnotation	associated		PD	16551910
PA449841	haloperidol	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10096261, 10942177, 11560558, 11595402, 12746736, 12784098, 12919180, 12960748, 14499311, 17667795, 26514968, 27023437, 27469576, 29472872, 9352580
PA449900	hydrocodone	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	12920424, 16631290, 20837591, 24269714, 25621429, 7693389, 9352573
PA449918	hydromorphone	Chemical	VariantAnnotation	associated	PK	PD	17986163
PA449969	imipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10460069, 11682257, 12360109, 1346258, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 1527229, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18070221, 18359183, 20531370, 2293406, 23486447, 2741190, 3356084, 3533565, 3769385, 7640151, 7965806, 8181196, 8867869, 8941025, 9014200, 9585799, 9918137
PA450149	ketoprofen	Chemical	ClinicalAnnotation	associated		PD	25989235
PA450150	ketorolac	Chemical	VariantAnnotation	associated		PD	17986163
PA450203	leuprolide	Chemical	VariantAnnotation	not associated		PD
PA450272	lovastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	associated	PK		22281720
PA450322	maprotiline	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous		PD
PA450338	meclizine	Chemical	LabelAnnotation	associated
PA450401	methadone	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11270921, 17178267, 17234366, 17502774, 17725248, 26968424, 29333880, 30907440
PA450464	methylphenidate	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	ambiguous	PK	PD	10831022, 17224704, 23526481
PA450475	metoclopramide	Chemical	LabelAnnotation, VariantAnnotation	ambiguous		PD	21840870
PA450480	metoprolol	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10471072, 11470994, 11692084, 11823760, 15467211, 15592325, 15726636, 18784654, 18834373, 19037197, 20643254, 24193112, 31107373
PA450488	mexiletine	Chemical	VipGene	associated
PA450522	mirtazapine	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	ambiguous	PK	PD	14514498, 14652703, 15538128, 17329996, 19071885, 19429471, 22926595, 23545896
PA450530	modafinil	Chemical	LabelAnnotation	associated
PA450550	morphine	Chemical	VariantAnnotation, VipGene	associated		PD	17986163, 19523031, 8351162
PA450603	nefazodone	Chemical	LabelAnnotation	associated
PA450616	nevirapine	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD
PA450626	nicotine	Chemical	Literature, MultilinkAnnotation, VariantAnnotation	associated		PD	24611668, 26287939
PA450657	nortriptyline	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10460069, 10770451, 11673748, 11682257, 12360109, 12814461, 1346258, 14520122, 14646691, 14652703, 14716707, 15115913, 15205367, 15252821, 15483356, 15590749, 16024198, 16361630, 16778723, 16871470, 17008819, 17470523, 17667959, 17721180, 18070221, 18359183, 20531370, 22389859, 23486447, 23799451, 24257813, 25761838, 4082245, 6111662, 8093319, 8181196, 8867869, 8941025, 9585799, 9797795, 9918137
PA450688	olanzapine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	11699614, 11901361, 12640212, 18223460, 19000940, 27251229
PA450705	ondansetron	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	12065557, 15731591, 20488759, 21596874, 21840870
PA450741	oxycodone	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	11207001, 12422998, 12920424, 16631290, 17986163, 19281600, 19719813, 19755414, 23783165, 8803381, 9352573
PA450748	oxymorphone	Chemical	VariantAnnotation	associated	PK
PA450801	paroxetine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	10434486, 10505591, 10824636, 11401659, 12057035, 12173784, 12352271, 12404686, 12870705, 14514498, 14639062, 14652703, 1531950, 1531951, 15349705, 15367050, 15544025, 15570195, 16319918, 16423440, 16534507, 16633156, 16669849, 17256449, 17541852, 18070221, 18609433, 18641553, 19743889, 20075642, 20174590, 22775532, 23437966, 23545896, 24868171, 25974703, 27187662, 28933337, 8941025, 9429230
PA450882	perphenazine	Chemical	LabelAnnotation, VipGene	associated			2743709
PA450947	phenytoin	Chemical	VariantAnnotation	associated	PK		24915025
PA450965	pimozide	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	associated	PK	PD	23059146, 9951426
PA450966	pindolol	Chemical	VariantAnnotation	not associated		PD	18784654
PA451103	primaquine	Chemical	MultilinkAnnotation, VariantAnnotation	ambiguous	PK	PD	24088113, 25518709, 30366777
PA451128	promethazine	Chemical	VariantAnnotation	associated		PD	17986163
PA451131	propafenone	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PK	PD	12421483, 14653957, 17001296, 17460029, 2713973
PA451145	propranolol	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	12728976, 9399616
PA451168	protriptyline	Chemical	LabelAnnotation	associated
PA451201	quetiapine	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	associated		PD	16871470, 29472872
PA451209	quinidine	Chemical	GuidelineAnnotation, LabelAnnotation	associated
PA451213	quinine	Chemical	LabelAnnotation	associated
PA451221	raloxifene	Chemical	VariantAnnotation	not associated	PK	PD
PA451257	risperidone	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10639689, 11791898, 11985287, 15260906, 15565299, 15669884, 15729081, 16160620, 16633140, 16833023, 17715206, 20332423, 20814331, 22592207, 22775532, 23609392, 24026091, 24232129, 24329187, 24589909, 24643635, 24828442, 25042870, 26129906, 26514968, 26544071, 26780783, 26872113, 26944100, 28389049, 29472872, 30870237
PA451260	ritonavir	Chemical	LabelAnnotation, Literature, MultilinkAnnotation	associated			24433361
PA451333	sertraline	Chemical	ClinicalAnnotation, GuidelineAnnotation, VariantAnnotation	ambiguous	PK	PD	18677622, 23545896
PA451363	simvastatin	Chemical	Pathway, VariantAnnotation	ambiguous	PK	PD	17700359, 26367500
PA451457	sotalol	Chemical	GuidelineAnnotation, VariantAnnotation	ambiguous		PD	18784654
PA451581	tamoxifen	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	14652237, 15632378, 15952058, 16361630, 16815318, 16877740, 17115111, 17761971, 18024866, 18294285, 18407954, 18794105, 19156902, 19189210, 19189212, 19596663, 20309015, 20454926, 20515869, 20574415, 20809362, 20849243, 21437611, 21451508, 21823108, 21830868, 21947681, 22180457, 22623212, 23100173, 23167378, 23289191, 23570465, 23712329, 23842856, 23962908, 24062210, 24125101, 24265036, 24329190, 24647041, 24682508, 24685597, 24744093, 24915025, 25211580, 26192892, 26681084, 26847054, 27109434, 27484880, 27797974, 29436156, 30022682
PA451583	tamsulosin	Chemical	LabelAnnotation	associated
PA451614	terbinafine	Chemical	LabelAnnotation	associated
PA451666	thioridazine	Chemical	ClinicalAnnotation, LabelAnnotation, VipGene	associated	PK		19604081, 2007317
PA451690	timolol	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PK	PD	16315032, 7474246
PA451735	tramadol	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	12191703, 12893130, 14499440, 14624403, 15906019, 16129989, 16368820, 16631290, 16763825, 16960721, 17175164, 17361124, 17470523, 17667796, 18204346, 18317231, 18520597, 18713907, 19514130, 20456744, 20488759, 21691803, 22428763, 24624916, 24709712, 24849324, 24968714, 25560051, 25647677, 25948472, 25989235, 26926096, 27082504, 29555325, 30784356, 8988065, 9476037
PA451791	trimipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	associated	PK	PD	10460069, 10774635, 11682257, 12360109, 1346258, 14520122, 14646691, 14716707, 15115913, 15205367, 15252821, 1527229, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18359183, 20531370, 23486447, 8181196, 8867869, 9585799, 9918137
PA451866	venlafaxine	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	ambiguous	PK	PD	10774634, 10780263, 10877013, 12544511, 14652703, 16044105, 16642541, 16958828, 17008819, 17803873, 18214456, 19822698, 23332809, 23357843, 23545896, 23799451, 24014145, 24858822, 25510856, 26406933, 28480819, 8941025
PA451946	yohimbine	Chemical	VipGene	associated			15289791
PA452229	antidepressants	Chemical	ClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK	PD	10460069, 11682257, 12360109, 1346258, 14520122, 14646691, 14716707, 15115913, 15116051, 15205367, 15252821, 16024198, 16361630, 16871470, 17008819, 17667959, 17721180, 18359183, 20531370, 27023676, 8181196, 8867869, 8941025, 9585799, 9918137
PA452233	antipsychotics	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10579557, 11214775, 12629505, 12960748, 15118351, 15861039, 16478753, 18346175, 20877299, 9068770, 9201806, 9713905, 9713906
PA452610	sparteine	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK		10471060, 15618746, 17001296, 17460029, 1844820, 18784265, 2211621, 7845481, 8287064, 8530011, 8563771, 8655150, 8946471, 9089660, 9241659, 9511177
PA452616	debrisoquine	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10022755, 10471060, 11470994, 11692084, 11823760, 11950793, 12439227, 15592325, 15618746, 15726636, 17470523, 1844820, 18784265, 2211621, 24279852, 26211952, 26652007, 7550367, 7935325, 8101460, 8530011, 8807669, 8946471, 9241659, 9918137
PA452618	opioids	Chemical	VariantAnnotation	associated		PD	17986163
PA452621	antineoplastic agents	Chemical	VariantAnnotation	ambiguous	PK	PD	15952058, 18407954, 18794105, 19156902, 19189210, 20574415, 20809362, 21437611, 21830868, 22623212, 23167378, 23570465, 23842856, 24682508, 25211580
PA452629	zuclopenthixol	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	associated	PK		12107620, 1927573

References

Pubmed ID	Year	Title	Citations
37747773	2024	Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.	0
37803948	2024	Investigation of the Differences in the Pharmacokinetics of CYP2D6 Substrates, Desipramine, and Dextromethorphan in Healthy African Subjects Carrying the Allelic Variants CYP2D617 and CYP2D629, When Compared with Normal Metabolizers.	0
38050015	2024	Novel Independent Trans- and Cis-Genetic Variants Associated with CYP2D6 Expression and Activity in Human Livers.	0
38059315	2024	Effects of CYP2D6 10 and 41 Variants in Healthy Chinese Men on the Pharmacokinetics of Dapoxetine.	0
38199567	2024	Functional maturation of cytochromes P450 3A4 and 2D6 relies on GAPDH- and Hsp90-Dependent heme allocation.	1
38236047	2024	CYP2D6 Genotyping and Inhibition as Predictors of Adverse Drug Reactions in Depressive Disorders.	0
38254077	2024	A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential 'culprit' for the tramadol 'abuse crisis'.	0
38372405	2024	Prevalence of CYP2D6 structural variation in large retrospective study.	0
39025838	2024	Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis.	0
37747773	2024	Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.	0
37803948	2024	Investigation of the Differences in the Pharmacokinetics of CYP2D6 Substrates, Desipramine, and Dextromethorphan in Healthy African Subjects Carrying the Allelic Variants CYP2D617 and CYP2D629, When Compared with Normal Metabolizers.	0
38050015	2024	Novel Independent Trans- and Cis-Genetic Variants Associated with CYP2D6 Expression and Activity in Human Livers.	0
38059315	2024	Effects of CYP2D6 10 and 41 Variants in Healthy Chinese Men on the Pharmacokinetics of Dapoxetine.	0
38199567	2024	Functional maturation of cytochromes P450 3A4 and 2D6 relies on GAPDH- and Hsp90-Dependent heme allocation.	1
38236047	2024	CYP2D6 Genotyping and Inhibition as Predictors of Adverse Drug Reactions in Depressive Disorders.	0

Citation

Dessen P

CYP2D6 (cytochrome P450 family 2 subfamily D member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40246