CYP2S1 (cytochrome P450 family 2 subfamily S member 1)

2003-06-01  

Identity

HGNC
CYP2S1
LOCATION
19q13.2
LOCUSID
29785
ALIAS
CYPIIS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29785
MIM: 611529
HGNC: 15654
Ensembl: ENSG00000167600

Variants:

dbSNP: 29785
ClinVar: 29785
TCGA: ENSG00000167600
COSMIC: CYP2S1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167600ENST00000310054Q96SQ9
ENSG00000167600ENST00000593545M0R2G8
ENSG00000167600ENST00000593890M0QYI2
ENSG00000167600ENST00000595590M0QY51
ENSG00000167600ENST00000597754M0R152
ENSG00000167600ENST00000600561M0R057

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355353912022CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction.1
359023792022CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.1
355353912022CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction.1
359023792022CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.1
329247832021CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis.4
333772612021Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.7
342758952021Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration.5
329247832021CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis.4
333772612021Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.7
342758952021Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration.5
323857432020PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.4
329131912020CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers.4
323857432020PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.4
329131912020CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers.4
300199952018Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.2

Citation

Dessen P

CYP2S1 (cytochrome P450 family 2 subfamily S member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40249