CYP3A5 (cytochrome P450 family 3 subfamily A member 5)

2003-08-01 Affiliation

Identity

HGNC

CYP3A5

LOCATION

7q22.1

LOCUSID

1577

ALIAS

CP35,CYPIIIA5,P450PCN3,PCN3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1577
MIM: 605325
HGNC: 2638
Ensembl: ENSG00000106258

Variants:

dbSNP: 1577
ClinVar: 1577
TCGA: ENSG00000106258
COSMIC: CYP3A5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106258	ENST00000222982	P20815
ENSG00000106258	ENST00000339843	Q7Z3N0
ENSG00000106258	ENST00000439761	P20815
ENSG00000106258	ENST00000456417	Q7Z3N0
ENSG00000106258	ENST00000646887	P20815

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
Aflatoxin activation and detoxification	REACTOME	R-HSA-5423646

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10075	esomeprazole	Chemical	VipGene	associated			18695978
PA10229	vardenafil	Chemical	ClinicalAnnotation	associated	PK		21934637
PA10251	atazanavir	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK
PA10333	tadalafil	Chemical	VipGene	associated			18695978
PA10804	imatinib	Chemical	ClinicalAnnotation	associated	PK		27426203
PA133888799	Organ Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	12966368, 20368718, 21806386, 22886152, 23073208, 23354298, 23557867, 23588314, 24522145, 24628014, 24658827, 24691060, 25976223, 26458301, 27653228, 28605053, 28952408, 29043387, 29135906, 29161757, 29441922, 29920880
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134308647	rosuvastatin	Chemical	ClinicalAnnotation	associated		PD	20207952
PA134850491	Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	12966368, 15707415, 16815317, 17941052, 20368718, 21806386, 22094953, 22886152, 23354298, 23557867, 23974086, 24522145, 24658827, 24691060, 25976223, 26543771, 27653228, 28245187, 28952408, 29043387, 29135906, 29318894, 29441922
PA154410481	prasugrel	Chemical	LabelAnnotation, Literature, MultilinkAnnotation	associated			21828263
PA157379134	Myalgia unspecified	Disease	ClinicalAnnotation	associated	PK	PD	15284534, 15900215, 16321621, 17192506, 17289397, 18727922, 23252946, 24598718, 26164721
PA162263533	nephrotoxicity	Disease	ClinicalAnnotation, MultilinkAnnotation	associated	PK	PD	17495880, 17700595, 18582803, 19067682, 19125240, 19545678, 19644155, 20526235, 21076384, 21544031, 21677300, 22369694, 23574377, 24052064, 24297552, 24625991, 25201288, 25673014, 26518946, 27717793, 29161757, 29550576, 29735966
PA162372840	sunitinib	Chemical	ClinicalAnnotation	associated		PD	22015057, 24013576
PA162630444	eszopiclone	Chemical	VipGene	associated			18695978
PA164746311	everolimus	Chemical	ClinicalAnnotation	associated	PK		24628014, 26458301
PA164746334	cilostazol	Chemical	ClinicalAnnotation	associated	PK
PA164748728	mycophenolic acid	Chemical	Pathway	associated			24220207
PA164768835	maraviroc	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	30192390
PA164924493	axitinib	Chemical	Literature, MultilinkAnnotation	associated			24433361
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated	PK	PD	24438215
PA165110351	Dabigatran	Chemical	ClinicalAnnotation	associated	PK		32564268
PA165111698	artemether	Chemical	Pathway	associated
PA165111722	lumefantrine	Chemical	ClinicalAnnotation	associated	PK	PD
PA165260403	arteether	Chemical	Pathway	associated
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12694072, 12966368, 14578760, 15167702, 15729180, 15808586, 16146556, 16249748, 16753004, 17430486, 17635182, 18334918, 18443548, 19067682, 19125240, 19258929, 19343327, 19545678, 20041908, 20383212, 20818295, 21047202, 21273673, 21331500, 21366650, 21436775, 21480817, 21528942, 21544031, 21566507, 21677300, 21711429, 21770725, 21806386, 21851254, 21886016, 21903774, 21922127, 22101623, 22183771, 22304537, 22310591, 22369694, 22469198, 22704849, 22786571, 22871995, 23073468, 23146466, 23146479, 23149441, 23557867, 23666583, 23778326, 23837477, 23953533, 24024898, 24033383, 24052064, 24089074, 24120259, 24238261, 24383873, 24444408, 24625991, 24628014, 24655974, 24656015, 24691060, 24739669, 24875272, 25271728, 25303300, 25322286, 25487141, 25817604, 25976223, 26177012, 26227094, 26458301, 26518946, 26615671, 26635230, 26714287, 26784512, 26915847, 26990259, 26990694, 27110018, 27138785, 27225724, 27266721, 27977332, 28030534, 28094348, 28401703, 28540692, 28605053, 28704257, 28736028, 28945481, 29043387, 29135906, 29161757, 29162334, 29318894, 29393157, 29441922, 29454235, 29535109, 29539600, 29550576, 29691732, 29731062, 29733390, 29804290, 29920880, 30704156
PA165948902	boceprevir	Chemical	LabelAnnotation	associated
PA165971505	CYP3A5*3A	Haplotype	VipGene	associated			12065767, 12439220, 12694072, 12754175, 12893984, 14515058, 15114431, 15147425, 15179406, 15284534, 15289787, 15450954, 15596297, 15723604, 15729180, 15808586, 15821045, 15900215, 16146556, 16338276, 17192769, 18727922, 19067682, 19229255, 19290795, 19494792, 19530969, 19681975, 20170205, 20393454, 21039054, 21418106, 21814220, 22015057, 22123129, 8878381, 11279519
PA166048680	CYP3A4*22	Haplotype	GuidelineAnnotation	associated
PA166048714	Pregnancy	Disease	ClinicalAnnotation	associated	PK		22875663
PA166114454	transplant rejection	Disease	ClinicalAnnotation	associated	PK	PD	16906020, 17430486, 18334918, 18443548, 19067682, 19125240, 19343327, 19545678, 21076384, 21886016, 22310591, 22786571, 23149441, 23837476, 23900887, 24438215, 24656015, 24739669, 24911663, 25201288, 25894154, 26177012, 26518946, 26635230, 28030534, 28157649, 29043387, 29161757, 29441922, 29550576, 29621122, 29689130, 29735966, 29878980
PA166114457	lung transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	12694072, 12966368, 14578760, 15167702, 15808586, 16146556, 16249748, 16753004, 17430486, 18334918, 19067682, 19125240, 19258929, 19343327, 19545678, 20041908, 20383212, 20818295, 21047202, 21273673, 21331500, 21480817, 21528942, 21566507, 21677300, 21711429, 21770725, 21851254, 21886016, 21922127, 22101623, 22183771, 22304537, 22310591, 22369694, 22469198, 22704849, 22871995, 23073468, 23146466, 23146479, 23149441, 23666583, 23837477, 24024898, 24033383, 24089074, 24120259, 24444408, 24655974, 24656015, 24739669, 25322286, 25817604, 26177012, 26227094, 26518946, 26635230, 26714287, 26915847, 26990694, 27138785, 27225724, 27266721, 27977332, 28030534, 28401703, 28540692, 28605053, 29161757, 29162334, 29393157, 29535109, 29539600, 29691732, 29731062, 29920880, 30704156
PA166114458	heart transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12694072, 12966368, 14578760, 15167702, 15808586, 16146556, 16249748, 16753004, 17430486, 18334918, 19067682, 19125240, 19258929, 19343327, 19545678, 20041908, 20383212, 20818295, 21047202, 21273673, 21331500, 21480817, 21528942, 21566507, 21677300, 21711429, 21770725, 21851254, 21886016, 21922127, 22101623, 22183771, 22304537, 22310591, 22369694, 22469198, 22704849, 22871995, 23073468, 23146466, 23146479, 23149441, 23666583, 23837477, 24024898, 24033383, 24089074, 24120259, 24444408, 24628014, 24655974, 24656015, 24739669, 25322286, 25817604, 26177012, 26227094, 26458301, 26518946, 26635230, 26714287, 26915847, 26990694, 27138785, 27225724, 27266721, 27977332, 28030534, 28401703, 28540692, 28605053, 29161757, 29162334, 29393157, 29535109, 29539600, 29691732, 29731062, 29920880, 30251062, 30704156
PA166114961	dolutegravir	Chemical	LabelAnnotation	associated
PA166122646	hemopoietic stem cell transplant	Disease	ClinicalAnnotation	associated	PK	PD	12694072, 12966368, 14578760, 15167702, 15808586, 16146556, 16249748, 16753004, 17430486, 18334918, 19067682, 19125240, 19258929, 19343327, 19545678, 20041908, 20383212, 20818295, 21047202, 21273673, 21331500, 21480817, 21528942, 21566507, 21677300, 21711429, 21770725, 21851254, 21886016, 21922127, 22101623, 22183771, 22304537, 22310591, 22369694, 22469198, 22704849, 22871995, 23073468, 23146466, 23146479, 23149441, 23666583, 23837477, 24024898, 24033383, 24089074, 24120259, 24444408, 24655974, 24656015, 24739669, 25322286, 25817604, 26177012, 26227094, 26518946, 26635230, 26714287, 26915847, 26990694, 27138785, 27225724, 27266721, 27977332, 28030534, 28401703, 28540692, 28605053, 29161757, 29162334, 29393157, 29535109, 29539600, 29691732, 29731062, 29920880, 30704156
PA166124478	endoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166127651	n-desmethyltamoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166127652	4-hydroxytamoxifen	Chemical	VariantAnnotation	not associated	PK		29436156
PA166128213	CYP3A5*1	Haplotype	LabelAnnotation	associated
PA166128219	CYP3A5*3	Haplotype	GuidelineAnnotation, VipGene	associated			12065767, 12439220, 12694072, 12754175, 12893984, 14515058, 15114431, 15147425, 15179406, 15284534, 15289787, 15450954, 15596297, 15723604, 15729180, 15808586, 15821045, 15900215, 15955870, 16146556, 16338276, 17192769, 18727922, 19067682, 19229255, 19290795, 19494792, 19530969, 19681975, 20170205, 20393454, 21039054, 21418106, 21814220, 22015057, 22123129, 8878381, 11279519
PA166128233	CYP3A5*6	Haplotype	VipGene	associated			11740341, 12756511, 12893984, 15596297, 15955870, 19229255, 11279519
PA166128234	CYP3A5*7	Haplotype	VipGene	associated			12324482, 12893984, 18211618, 11740341
PA166157267	rs776746	Variant	VipGene	associated			12065767, 12439220, 12694072, 12754175, 12893984, 14515058, 15114431, 15147425, 15179406, 15284534, 15289787, 15450954, 15596297, 15723604, 15729180, 15808586, 15821045, 15900215, 16146556, 16338276, 17192769, 18727922, 19067682, 19229255, 19290795, 19494792, 19530969, 19681975, 20170205, 20393454, 21039054, 21418106, 21814220, 22015057, 22123129, 8878381, 11279519
PA166157441	rs10264272	Variant	VipGene	associated			11740341, 12756511, 12893984, 15596297, 19229255, 11279519
PA166157517	rs76293380	Variant	VipGene	associated			12324482, 12893984, 18211618, 11740341
PA166163740	apixaban	Chemical	ClinicalAnnotation	associated	PK		28678049, 29457840
PA166169562	laparoscopic sleeve gastrectomy	Disease	VariantAnnotation	associated	PK		28342282
PA166183939	dextropropoxyphene	Chemical	ClinicalAnnotation	associated	PK		20133509
PA443425	Arteriosclerosis	Disease	ClinicalAnnotation	associated		PD	15284534
PA443434	Arthritis, Rheumatoid	Disease	VariantAnnotation	associated	PK
PA443459	Atrial Fibrillation	Disease	ClinicalAnnotation	associated	PK		28678049, 29457840
PA443560	Breast Neoplasms	Disease	VariantAnnotation, VipGene	ambiguous	PK		19229255, 15596297, 29436156
PA443624	Carcinoma, Renal Cell	Disease	ClinicalAnnotation	associated		PD	22015057, 24013576
PA443750	Colitis, Ulcerative	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	24033383, 27717793, 28135009
PA443899	Diarrhea	Disease	VariantAnnotation	associated		PD	23953533
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	23252947, 24384557, 25495409, 26421491
PA444516	Hypercholesterolemia	Disease	ClinicalAnnotation	associated	PK	PD	15284534, 16321621, 17192506, 17289397, 18727922, 23252946, 24598718, 26164721
PA444528	Hyperlipidemias	Disease	ClinicalAnnotation	associated		PD	21047202
PA444552	Hypertension	Disease	ClinicalAnnotation, VipGene	associated		PD	21814220, 19290795, 21677300, 21851254, 23146466, 24625991
PA444614	Infection	Disease	ClinicalAnnotation	associated	PK	PD	22210422, 22310591, 24438215, 24625991, 24656015, 26518946
PA444750	Leukemia	Disease	VariantAnnotation	associated	PK		26232156
PA444822	Lupus Erythematosus, Systemic	Disease	VariantAnnotation	associated	PK
PA444859	Malaria	Disease	ClinicalAnnotation	associated	PK	PD
PA445004	Myasthenia Gravis	Disease	VariantAnnotation	associated	PK		29611886
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated		PD	20207952
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	22277678, 30281924
PA445089	Nephrotic Syndrome	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		29637588
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation	associated		PD	26179145
PA445208	Pain	Disease	ClinicalAnnotation	associated	PK	PD	22277678, 24365989, 27236640, 30281924
PA445210	Pain, Postoperative	Disease	ClinicalAnnotation	associated	PK		22277678, 24365989, 27236640, 30281924
PA446166	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Disease	VipGene	associated			21418106, 21039054
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	ClinicalAnnotation	associated	PK		27426203
PA446438	Kidney Failure	Disease	ClinicalAnnotation	associated	PK	PD	18408564, 26856709
PA446975	Neurotoxicity Syndromes	Disease	ClinicalAnnotation	associated		PD	20030680, 22369694, 26856709
PA447230	HIV Infections	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	15622315, 16267764, 19228205, 20017669, 20625352, 20860463, 21824325, 24477223, 30192390
PA447247	liver transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15226679, 16421475, 16424824, 16628701, 17015051, 17568575, 17875118, 18408564, 19289993, 19384171, 21047202, 21359536, 21886016, 21922127, 22210422, 22309416, 22422348, 23107770, 23837476, 23894093, 23900887, 24351870, 24378577, 24438215, 24820765, 24911663, 25141896, 25712187, 25869250, 25966085, 26176181, 26450467, 26518936, 26634478, 26856709, 27320564, 27503662, 27653228, 28941036, 29318894, 29454235, 29621122, 29855074
PA448333	alprazolam	Chemical	Pathway, VipGene	associated			18695978
PA448383	amiodarone	Chemical	VipGene	associated			18695978
PA448388	amlodipine	Chemical	ClinicalAnnotation	associated	PK		17178265
PA448500	atorvastatin	Chemical	ClinicalAnnotation, Pathway, VipGene	associated		PD	15284534, 15900215, 16103896, 17289397, 18695978, 18727922
PA448685	buprenorphine	Chemical	VipGene	associated			18695978
PA448689	buspirone	Chemical	VipGene	associated			18695978
PA448785	carbamazepine	Chemical	ClinicalAnnotation, Pathway, VipGene	associated	PK	PD	18695978, 21738081, 23252947, 24384557, 25495409, 26421491
PA448803	carboplatin	Chemical	ClinicalAnnotation	associated		PD	26179145
PA448871	celecoxib	Chemical	VipGene	associated			18695978
PA448960	chlorpheniramine	Chemical	VipGene	associated			18695978
PA449015	citalopram	Chemical	VipGene	associated			18695978
PA449028	clarithromycin	Chemical	VipGene	associated			18695978
PA449035	clindamycin	Chemical	VipGene	associated			18695978
PA449053	clopidogrel	Chemical	Literature, MultilinkAnnotation, Pathway, VipGene	associated			20938371, 21828263
PA449160	cyclobenzaprine	Chemical	VipGene	associated			18695978
PA449167	cyclosporine	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	12966368, 20368718, 21806386, 22886152, 23354298, 23557867, 23922006, 24522145, 24658827, 24691060, 25976223, 27653228, 28952408, 29043387, 29135906, 29441922
PA449283	diazepam	Chemical	VipGene	associated			18695978
PA449383	docetaxel	Chemical	Pathway	associated			21151855
PA449394	donepezil	Chemical	VipGene	associated			18695978
PA449441	efavirenz	Chemical	ClinicalAnnotation	associated	PK		15622315, 16267764, 20625352, 20860463, 24477223
PA449493	erythromycin	Chemical	VipGene	associated			18695978
PA449527	ethinyl estradiol	Chemical	VipGene	associated			18695978
PA449594	fenofibrate	Chemical	VipGene	associated			18695978
PA449599	fentanyl	Chemical	ClinicalAnnotation, VipGene	associated	PK	PD	18695978, 22277678, 24365989, 27236640, 30281924
PA449673	fluoxetine	Chemical	Pathway, VipGene	associated			18695978
PA449686	fluticasone propionate	Chemical	VipGene	associated			18695978
PA449688	fluvastatin	Chemical	Pathway	associated
PA449809	granisetron	Chemical	ClinicalAnnotation	associated	PK		27809336
PA449841	haloperidol	Chemical	MultilinkAnnotation, VipGene	associated			18695978, 27023437
PA449900	hydrocodone	Chemical	VipGene	associated			18695978
PA449918	hydromorphone	Chemical	VipGene	associated			18695978
PA449943	hydroxyzine	Chemical	VipGene	associated			18695978
PA450128	isotretinoin	Chemical	VipGene	associated			18695978
PA450180	lansoprazole	Chemical	VipGene	associated			18695978
PA450264	lopinavir	Chemical	ClinicalAnnotation	associated	PK
PA450266	loratadine	Chemical	VipGene	associated			18695978
PA450268	losartan	Chemical	VipGene	associated			18695978
PA450272	lovastatin	Chemical	ClinicalAnnotation, Pathway, VipGene	associated		PD	15284534, 18695978
PA450344	medroxyprogesterone	Chemical	VipGene	associated			18695978
PA450353	meloxicam	Chemical	VipGene	associated			18695978
PA450369	meperidine	Chemical	VipGene	associated			18695978
PA450496	midazolam	Chemical	ClinicalAnnotation, MultilinkAnnotation, Pathway	associated	PK		23327575, 24214410, 25979262, 28986606
PA450522	mirtazapine	Chemical	VipGene	associated			18695978
PA450530	modafinil	Chemical	VipGene	associated			18695978
PA450546	montelukast	Chemical	VipGene	associated			18695978
PA450616	nevirapine	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	19228205, 20017669, 21824325
PA450631	nifedipine	Chemical	ClinicalAnnotation	associated	PK		22875663
PA450633	nimodipine	Chemical	ClinicalAnnotation	associated		PD	19205682
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PK		23559402
PA450704	omeprazole	Chemical	VipGene	associated			18695978
PA450705	ondansetron	Chemical	ClinicalAnnotation	associated	PK		21596874
PA450741	oxycodone	Chemical	ClinicalAnnotation, VipGene	associated		PD	18695978, 21209234
PA450761	paclitaxel	Chemical	ClinicalAnnotation	associated		PD	20212519, 26179145
PA450774	pantoprazole	Chemical	VipGene	associated			18695978
PA450801	paroxetine	Chemical	Pathway	associated
PA450970	pioglitazone	Chemical	VipGene	associated			18695978
PA451123	progesterone	Chemical	VipGene	associated			18695978
PA451142	propoxyphene	Chemical	VipGene	associated			18695978
PA451201	quetiapine	Chemical	ClinicalAnnotation, VipGene	associated	PK		18695978, 24240480
PA451250	rifampin	Chemical	VipGene	associated			18695978
PA451260	ritonavir	Chemical	ClinicalAnnotation	associated	PK
PA451300	salmeterol	Chemical	VipGene	associated			18695978
PA451333	sertraline	Chemical	VipGene	associated			18695978
PA451344	sibutramine	Chemical	VipGene	associated			18695978
PA451346	sildenafil	Chemical	VipGene	associated			18695978
PA451363	simvastatin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VipGene	associated	PK	PD	15284534, 16321621, 17192506, 17289397, 18695978, 23252946, 24598718, 26164721
PA451365	sirolimus	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PK	PD	15707415, 16815317, 17941052, 22094953, 23974086, 26256674, 26543771, 28245187
PA451527	sufentanil	Chemical	ClinicalAnnotation	associated		PD	31773688
PA451578	tacrolimus	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	12694072, 12966368, 14578760, 14747421, 15167702, 15226679, 15729180, 15808586, 16146556, 16249748, 16421475, 16424824, 16628701, 16753004, 16906020, 17015051, 17430486, 17495880, 17568575, 17635182, 17700595, 17875118, 18334918, 18408564, 18443548, 18582803, 19067682, 19125240, 19258929, 19289993, 19343327, 19384171, 19545678, 19644155, 20030680, 20041908, 20383212, 20526235, 20818295, 21047202, 21076384, 21273673, 21331500, 21359536, 21366650, 21436775, 21480817, 21528942, 21544031, 21566507, 21677300, 21711429, 21770725, 21806386, 21851254, 21886016, 21903774, 21922127, 22075549, 22101623, 22183771, 22210422, 22304537, 22309416, 22310591, 22339449, 22369694, 22422348, 22469198, 22704849, 22786571, 22871995, 23073208, 23073468, 23107770, 23146466, 23146479, 23149441, 23557867, 23574377, 23588314, 23666583, 23778326, 23837476, 23837477, 23894093, 23900887, 23922006, 23953533, 24024898, 24033383, 24052064, 24089074, 24120259, 24238261, 24351870, 24378577, 24383873, 24438215, 24444408, 24625991, 24655974, 24656015, 24739669, 24820765, 24875272, 24911663, 25141896, 25201288, 25271728, 25303300, 25310192, 25322286, 25487141, 25673014, 25712187, 25801146, 25817604, 25869250, 25894154, 25966085, 26176181, 26177012, 26227094, 26232156, 26450467, 26518936, 26518946, 26615671, 26634478, 26635230, 26714287, 26784512, 26856709, 26882121, 26915847, 26990259, 26990694, 27110018, 27138785, 27225724, 27266721, 27320564, 27503662, 27653228, 27717793, 27977332, 28030534, 28094348, 28135009, 28157649, 28342282, 28401703, 28540692, 28605053, 28704257, 28736028, 28941036, 28945481, 29043387, 29161757, 29162334, 29279557, 29318894, 29393157, 29441922, 29454235, 29535109, 29539600, 29550576, 29611886, 29621122, 29637588, 29689130, 29691732, 29731062, 29733390, 29735966, 29804290, 29855074, 29878980, 29920880, 30251062, 30704156
PA451581	tamoxifen	Chemical	Pathway, VariantAnnotation	ambiguous	PK		23962908, 29436156
PA451583	tamsulosin	Chemical	VipGene	associated			18695978
PA451612	terazosin	Chemical	VipGene	associated			18695978
PA451735	tramadol	Chemical	VipGene	associated			18695978
PA451744	trazodone	Chemical	VipGene	associated			18695978
PA451746	tretinoin	Chemical	VipGene	associated			18695978
PA451753	triazolam	Chemical	Pathway	associated
PA451866	venlafaxine	Chemical	VipGene	associated			18695978
PA451879	vincristine	Chemical	Pathway	associated
PA451906	warfarin	Chemical	VipGene	associated			18695978
PA451974	ziprasidone	Chemical	VipGene	associated			18695978
PA451976	zolpidem	Chemical	VipGene	associated

References

Pubmed ID	Year	Title	Citations
38262522	2024	The impact of CYP3A5*3 on oral quetiapine: A population pharmacokinetic model in Chinese bipolar disorder patients.	0
38262522	2024	The impact of CYP3A5*3 on oral quetiapine: A population pharmacokinetic model in Chinese bipolar disorder patients.	0
35471917	2023	CYP3A422 and CYP3A53 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.	1
36581339	2023	Evaluating the Impacts of CYP3A41B and CYP3A53 Variations on Pharmacokinetic Behavior and Clinical Outcomes in Multiple Myeloma Patients With Autologous Stem Cell Transplant.	0
36623883	2023	CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells.	0
36630936	2023	CYP3A5 Expressor Genotype of the Transplanted Kidney Increases the Risk of Preterm Graft Loss and Acute Rejection.	0
36688864	2023	Genetic association in CYP3A4 and CYP3A5 genes elevate the risk of prostate cancer.	0
36797680	2023	Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.	2
36877088	2023	Impact of CYP3A5 genotype on de-novo LCP tacrolimus dosing and monitoring in kidney transplantation.	0
36927114	2023	Impact of genetic polymorphisms on tacrolimus trough blood concentration in Chinese liver transplant recipients.	0
36974789	2023	Association of STAT3, CYP3A5, and ABCG2 Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients.	0
37340713	2023	Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients.	3
37420302	2023	The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation.	3
37759317	2023	Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?	0
37891021	2023	Tacrolimus and Diabetes in Kidney Transplantation: The Impact of Cyp3a5 Gene Polymorphism.	0

Citation

Dessen P

CYP3A5 (cytochrome P450 family 3 subfamily A member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40251