Identity
HGNC
LOCATION
1p33
LOCUSID
ALIAS
CP4Y,CYP4A2,CYP4AII,CYPIVA11
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1579
MIM: 601310
HGNC: 2642
Ensembl: ENSG00000187048
Variants:
dbSNP: 1579
ClinVar: 1579
TCGA: ENSG00000187048
COSMIC: CYP4A11
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA448368 | amiloride | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451483 | spironolactone | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32124935 | 2020 | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. | 17 |
| 32141150 | 2020 | New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients. | 3 |
| 32373936 | 2020 | The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis. | 0 |
| 32124935 | 2020 | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. | 17 |
| 32141150 | 2020 | New genetic variations discovered in KRAS wild-type cetuximab resistant chinese colorectal cancer patients. | 3 |
| 32373936 | 2020 | The role of cytochrome P450 gene rs1126742 polymorphism and risk of hypertension: a systematic review and meta-analysis. | 0 |
| 29484037 | 2018 | A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease. | 19 |
| 30132788 | 2018 | Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases. | 2 |
| 29484037 | 2018 | A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease. | 19 |
| 30132788 | 2018 | Genetic role of CYP4A11 polymorphisms in the risk of developing cardiovascular and cerebrovascular diseases. | 2 |
| 28533430 | 2017 | Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. | 14 |
| 28534704 | 2017 | Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population. | 9 |
| 28533430 | 2017 | Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. | 14 |
| 28534704 | 2017 | Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population. | 9 |
| 26423716 | 2016 | Cytochrome P450 Genetic Variants and Their Metabolite Levels Associated with Plaque Stability in Patients with Ischemic Stroke. | 20 |
Citation
Dessen P
CYP4A11 (cytochrome P450 family 4 subfamily A member 11)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40252/cyp4a11
