DCK (deoxycytidine kinase)

2003-06-01 Affiliation

Identity

HGNC

DCK

LOCATION

4q13.3

LOCUSID

1633

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1633
MIM: 125450
HGNC: 2704
Ensembl: ENSG00000156136

Variants:

dbSNP: 1633
ClinVar: 1633
TCGA: ENSG00000156136
COSMIC: DCK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156136	ENST00000286648	P27707
ENSG00000156136	ENST00000286648	F5CTF3
ENSG00000156136	ENST00000503359	D6RG38
ENSG00000156136	ENST00000504730	D6RCP9
ENSG00000156136	ENST00000504952	D6RFG8
ENSG00000156136	ENST00000509617	D6R9C6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Purine metabolism	REACTOME	R-HSA-73847
Purine salvage	REACTOME	R-HSA-74217
Pyrimidine metabolism	REACTOME	R-HSA-73848
Pyrimidine salvage reactions	REACTOME	R-HSA-73614

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444760	Leukemia, Myeloid, Acute	Disease	ClinicalAnnotation	associated	PK	PD	15564883
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation	associated		PD	20665488
PA449177	cytarabine	Chemical	ClinicalAnnotation	associated	PK	PD	15564883
PA449212	daunorubicin	Chemical	MultilinkAnnotation	associated			25119182
PA449748	gemcitabine	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway	associated	PK	PD	12477049, 20665488, 22705007, 23230131, 25162786
PA449961	idarubicin	Chemical	ClinicalAnnotation	associated	PK	PD	15564883
PA450163	lamivudine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38346958	2024	Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer.	1
38346958	2024	Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer.	1
34825941	2022	Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms.	1
34825941	2022	Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms.	1
33626530	2021	Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine.	4
34571370	2021	Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.	3
33626530	2021	Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine.	4
34571370	2021	Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.	3
32588770	2020	DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer.	2
32671914	2020	Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma.	3
32588770	2020	DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer.	2
32671914	2020	Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma.	3
28820179	2017	Effects of DCK knockdown on proliferation, apoptosis and tumorigenicity in vivo of cervical cancer HeLa cells.	5
28820179	2017	Effects of DCK knockdown on proliferation, apoptosis and tumorigenicity in vivo of cervical cancer HeLa cells.	5
26362587	2016	Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.	7

Citation

Dessen P

DCK (deoxycytidine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40270/gene-fusions-explorer/teaching-explorer/favicon/favicon-16x16.png