Identity
HGNC
LOCATION
10q25.3
LOCUSID
ALIAS
PSO2,SNM1,SNM1A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9937
MIM: 609682
HGNC: 17660
Ensembl: ENSG00000198924
Variants:
dbSNP: 9937
ClinVar: 9937
TCGA: ENSG00000198924
COSMIC: DCLRE1A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198924 | ENST00000361384 | Q6PJP8 |
| ENSG00000198924 | ENST00000369305 | Q6PJP8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| Fanconi Anemia Pathway | REACTOME | R-HSA-6783310 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38918391 | 2024 | SNM1A is crucial for efficient repair of complex DNA breaks in human cells. | 0 |
| 38918391 | 2024 | SNM1A is crucial for efficient repair of complex DNA breaks in human cells. | 0 |
| 34387696 | 2021 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. | 15 |
| 34387696 | 2021 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. | 15 |
| 32866775 | 2020 | The SNM1A DNA repair nuclease. | 14 |
| 32866775 | 2020 | The SNM1A DNA repair nuclease. | 14 |
| 30165656 | 2018 | Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink. | 12 |
| 30165656 | 2018 | Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink. | 12 |
| 28607004 | 2017 | RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. | 35 |
| 28607004 | 2017 | RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. | 35 |
| 26582912 | 2015 | The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. | 25 |
| 26582912 | 2015 | The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. | 25 |
| 22692201 | 2012 | Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. | 36 |
| 22692201 | 2012 | Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. | 36 |
| 21896658 | 2011 | Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. | 95 |
Citation
Dessen P
DCLRE1A (DNA cross-link repair 1A)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/40271/dclre1a
