DCLRE1B (DNA cross-link repair 1B)

2003-12-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
APOLLO,SNM1B,SNMIB

Other Information

Locus ID:

NCBI: 64858
MIM: 609683
HGNC: 17641
Ensembl: ENSG00000118655

Variants:

dbSNP: 64858
ClinVar: 64858
TCGA: ENSG00000118655
COSMIC: DCLRE1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118655ENST00000466480A0A3B3IT16
ENSG00000118655ENST00000648795A0A3B3IT16
ENSG00000118655ENST00000650450Q9H816
ENSG00000118655ENST00000650596A0A3B3ITQ0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
384073082024DNA-PK controls Apollo's access to leading-end telomeres.1
384309742024DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection.1
384073082024DNA-PK controls Apollo's access to leading-end telomeres.1
384309742024DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection.1
379360742023DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.0
379360742023DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.0
343876942021A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.4
343876962021Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.15
343876942021A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.4
343876962021Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.15
265829122015The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.25
265829122015The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.25
238634622013The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.14
238634622013The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.14
226922012012Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.36

Citation

Dessen P

DCLRE1B (DNA cross-link repair 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40272/haematological-explorer/tumors-explorer/js/web-card-_common.js