DCLRE1B (DNA cross-link repair 1B)

2003-12-01  

Identity

HGNC
DCLRE1B
LOCATION
1p13.2
LOCUSID
64858
ALIAS
APOLLO,SNM1B,SNMIB

Other Information

Locus ID:

NCBI: 64858
MIM: 609683
HGNC: 17641
Ensembl: ENSG00000118655

Variants:

dbSNP: 64858
ClinVar: 64858
TCGA: ENSG00000118655
COSMIC: DCLRE1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118655ENST00000466480A0A3B3IT16
ENSG00000118655ENST00000648795A0A3B3IT16
ENSG00000118655ENST00000650450Q9H816
ENSG00000118655ENST00000650596A0A3B3ITQ0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
384073082024DNA-PK controls Apollo's access to leading-end telomeres.1
384309742024DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection.1
384073082024DNA-PK controls Apollo's access to leading-end telomeres.1
384309742024DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection.1
379360742023DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.0
379360742023DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.0
343876942021A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.4
343876962021Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.15
343876942021A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.4
343876962021Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.15
265829122015The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.25
265829122015The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.25
238634622013The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.14
238634622013The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability.14
226922012012Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.36

Citation

Dessen P

DCLRE1B (DNA cross-link repair 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40272/teaching-explorer/favicon/teaching-explorer/