DDR2 (discoidin domain receptor tyrosine kinase 2)

2003-02-01  

Identity

HGNC
DDR2
LOCATION
1q23.3
LOCUSID
4921
ALIAS
MIG20a,NTRKR3,TKT,TYRO10,WRCN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4921
MIM: 191311
HGNC: 2731
Ensembl: ENSG00000162733

Variants:

dbSNP: 4921
ClinVar: 4921
TCGA: ENSG00000162733
COSMIC: DDR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162733ENST00000367921Q16832
ENSG00000162733ENST00000367921A0A024R906
ENSG00000162733ENST00000367922Q16832
ENSG00000162733ENST00000367922A0A024R906
ENSG00000162733ENST00000415555Q5T244
ENSG00000162733ENST00000446985Q16832
ENSG00000162733ENST00000446985A0A024R906

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171

References

Pubmed IDYearTitleCitations
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
381543562024METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer.2
385381062024DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms.0
379967002024DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.4
381543562024METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer.2
385381062024DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms.0
359048522023Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling.0
363702142023Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study.1
359048522023Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling.0
363702142023Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study.1
357118922022Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer.3
357611082022Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.4
367138122022DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1.0
357118922022Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer.3
357611082022Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.4

Citation

Dessen P

DDR2 (discoidin domain receptor tyrosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40281