DDX11 (DEAD/H-box helicase 11)

2003-02-01  

Identity

HGNC
DDX11
LOCATION
12p11.21
LOCUSID
1663
ALIAS
CHL1,CHLR1,KRG2,WABS

Other Information

Locus ID:

NCBI: 1663
MIM: 601150
HGNC: 2736
Ensembl: ENSG00000013573

Variants:

dbSNP: 1663
ClinVar: 1663
TCGA: ENSG00000013573
COSMIC: DDX11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013573ENST00000228264Q96FC9
ENSG00000013573ENST00000350437Q96FC9
ENSG00000013573ENST00000415475F5GXJ8
ENSG00000013573ENST00000435753Q96FC9
ENSG00000013573ENST00000438391C9K0E8
ENSG00000013573ENST00000535317F5GXL6
ENSG00000013573ENST00000538345H0YGX9
ENSG00000013573ENST00000539049F5H235
ENSG00000013573ENST00000539702H0YFY8
ENSG00000013573ENST00000540935F6WZM0
ENSG00000013573ENST00000542129B4DMS8
ENSG00000013573ENST00000542244F5GYY1
ENSG00000013573ENST00000542838Q96FC9
ENSG00000013573ENST00000543756F5H2V9
ENSG00000013573ENST00000544652R4GNE1
ENSG00000013573ENST00000545115H0YGL4
ENSG00000013573ENST00000545668Q96FC9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379936682024Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.0
384785952024Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.0
379936682024Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.0
384785952024Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.0
335916022021Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.1
342992442021Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.1
335916022021Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.1
342992442021Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.1
319352212020Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.13
320144242020DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11.15
320712822020The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.12
322714222020The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.18
323328802020E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.27
324225632020DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.7
327057082020Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.41

Citation

Dessen P

DDX11 (DEAD/H-box helicase 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40284/js/tumors-explorer/css/template-card.css