DDX49 (DEAD-box helicase 49)

2003-12-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
Dbp8,R27090_2
FUSION GENES

Other Information

Locus ID:

NCBI: 54555
HGNC: 18684
Ensembl: ENSG00000105671

Variants:

dbSNP: 54555
ClinVar: 54555
TCGA: ENSG00000105671
COSMIC: DDX49

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105671ENST00000247003Q9Y6V7
ENSG00000105671ENST00000593361M0QXD4
ENSG00000105671ENST00000594021M0QZC0
ENSG00000105671ENST00000595858M0R0K1
ENSG00000105671ENST00000598972M0R1S3
ENSG00000105671ENST00000602113M0QXD4
ENSG00000105671ENST00000629999M0R0K1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370948652023DDX49 Promotes Proliferation and Metastasis of Cervical Cancer by Regulation of AKT and Wnt/β-Catenin Signalings.0
371063392023Overexpression of DDX49 in prostate cancer is associated with poor prognosis.0
370948652023DDX49 Promotes Proliferation and Metastasis of Cervical Cancer by Regulation of AKT and Wnt/β-Catenin Signalings.0
371063392023Overexpression of DDX49 in prostate cancer is associated with poor prognosis.0
362986422022DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs.2
362986422022DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs.2
339527172021Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.3
339527172021Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.3
317492822020DDX49 is a novel biomarker and therapeutic target for lung cancer metastases.7
330899522020LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR-342 and upregulating DDX49.7
317492822020DDX49 is a novel biomarker and therapeutic target for lung cancer metastases.7
330899522020LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR-342 and upregulating DDX49.7
296181222018DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA.20
296181222018DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA.20

Citation

Dessen P

DDX49 (DEAD-box helicase 49)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40289/ddx49