PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

2003-05-01  

Identity

HGNC
PPM1K
LOCATION
4q22.1
LOCUSID
152926
ALIAS
BDP,MSUDMV,PP2Ckappa,PP2Cm,PTMP,UG0882E07
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 152926
MIM: 611065
HGNC: 25415
Ensembl: ENSG00000163644

Variants:

dbSNP: 152926
ClinVar: 152926
TCGA: ENSG00000163644
COSMIC: PPM1K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163644ENST00000295908A0A0A0MQZ4
ENSG00000163644ENST00000505022V9GYS8
ENSG00000163644ENST00000508256V9GY69
ENSG00000163644ENST00000510548V9GYI6
ENSG00000163644ENST00000514204V9GYZ5
ENSG00000163644ENST00000608933Q8N3J5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Branched-chain amino acid catabolismREACTOMER-HSA-70895

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368630882023PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.4
368630882023PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.4
339644022021The role of PP5 and PP2C in cardiac health and disease.8
343824952021Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.5
339644022021The role of PP5 and PP2C in cardiac health and disease.8
343824952021Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.5
304512842019Crystal structure and catalytic activity of the PPM1K N94K mutant.4
304512842019Crystal structure and catalytic activity of the PPM1K N94K mutant.4
298558042018Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.9
298558042018Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.9
287686542017Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial.17
287686542017Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial.17
265925132015Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.5
265925132015Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.5
234468282013Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.36

Citation

Dessen P

PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40324