DLG5 (discs large MAGUK scaffold protein 5)

2003-06-01  

Identity

HGNC
DLG5
LOCATION
10q22.3
LOCUSID
9231
ALIAS
LP-DLG,P-DLG5,PDLG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9231
MIM: 604090
HGNC: 2904
Ensembl: ENSG00000151208

Variants:

dbSNP: 9231
ClinVar: 9231
TCGA: ENSG00000151208
COSMIC: DLG5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151208ENST00000372391Q8TDM6
ENSG00000151208ENST00000424842A0A0A0MSL1
ENSG00000151208ENST00000468332R4GMQ2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA448771capecitabineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
370011862023A double-edged sword: DLG5 in diseases.2
370011862023A double-edged sword: DLG5 in diseases.2
349844672022The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells.7
356384312022Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.2
349844672022The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells.7
356384312022Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.2
326318162021DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes.7
326318162021DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes.7
304507662019DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.15
304507662019DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.15
281693602017Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.32
283901572017Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.20
281693602017Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.32
283901572017Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.20
268983452016Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma.12

Citation

Dessen P

DLG5 (discs large MAGUK scaffold protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40335/dlg5