DMP1 (dentin matrix acidic phosphoprotein 1)

2003-05-01 Affiliation

Identity

HGNC

DMP1

LOCATION

4q22.1

LOCUSID

1758

ALIAS

ARHP,ARHR,DMP-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1758
MIM: 600980
HGNC: 2932
Ensembl: ENSG00000152592

Variants:

dbSNP: 1758
ClinVar: 1758
TCGA: ENSG00000152592
COSMIC: DMP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152592	ENST00000282479	Q13316
ENSG00000152592	ENST00000339673	Q13316

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Extracellular matrix organization	REACTOME	R-HSA-1474244
ECM proteoglycans	REACTOME	R-HSA-3000178

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36315908	2023	First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.	0
36315908	2023	First report in Argentina of a pathogenic DMP1 variant associated with autosomal recessive hypophosphatemic rickets.	0
35981698	2022	Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A modification.	2
36482408	2022	Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets.	1
35981698	2022	Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A modification.	2
36482408	2022	Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets.	1
33420898	2021	DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.	8
33420898	2021	DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.	8
29278708	2018	Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.	5
29289709	2018	Periostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament.	4
29278708	2018	Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.	5
29289709	2018	Periostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament.	4
28247029	2017	In focus in HCB.	0
28247029	2017	In focus in HCB.	0
25678029	2016	Immunolocalization of dentin matrix protein-1 in human primary teeth treated with different pulp capping materials.	12

Citation

Dessen P

DMP1 (dentin matrix acidic phosphoprotein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

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