TRDMT1 (tRNA aspartic acid methyltransferase 1)

2003-02-01  

Identity

HGNC
TRDMT1
LOCATION
10p13
LOCUSID
1787
ALIAS
DMNT2,DNMT2,MHSAIIP,PUMET,RNMT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1787
MIM: 602478
HGNC: 2977
Ensembl: ENSG00000107614

Variants:

dbSNP: 1787
ClinVar: 1787
TCGA: ENSG00000107614
COSMIC: TRDMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107614ENST00000313936H0Y2T8
ENSG00000107614ENST00000354631Q7Z3E4
ENSG00000107614ENST00000377799O14717
ENSG00000107614ENST00000377799Q6ICS7
ENSG00000107614ENST00000424636A0A0C4DG18
ENSG00000107614ENST00000436968H0Y4A2
ENSG00000107614ENST00000488990B7Z8H2
ENSG00000107614ENST00000495022O14717
ENSG00000107614ENST00000495022A0A0U1SZ86
ENSG00000107614ENST00000525762A0A0B4J214

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362733762023DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis.5
362733762023DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis.5
341007722021TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.8
341396732021The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.18
348714552021Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2.8
341007722021TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.8
341396732021The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.18
348714552021Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2.8
333315372020Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation.0
333694582020Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma.5
333315372020Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation.0
333694582020Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma.5
315701652019Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration.34
315701652019Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration.34
284767762017Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection.33

Citation

Dessen P

TRDMT1 (tRNA aspartic acid methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40348