DOK1 (docking protein 1)

2003-02-01  

Identity

HGNC
DOK1
LOCATION
2p13.1
LOCUSID
1796
ALIAS
P62DOK,pp62

Other Information

Locus ID:

NCBI: 1796
MIM: 602919
HGNC: 2990
Ensembl: ENSG00000115325

Variants:

dbSNP: 1796
ClinVar: 1796
TCGA: ENSG00000115325
COSMIC: DOK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115325ENST00000233668Q99704
ENSG00000115325ENST00000340004Q99704
ENSG00000115325ENST00000409429Q99704
ENSG00000115325ENST00000429631H7C093

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Signal TransductionREACTOMER-HSA-162582
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1REACTOMER-HSA-8849469
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375070232023Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.2
375070232023Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.2
347277482021Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.1
347277482021Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.1
319197522020Analysis of the DOK1 gene in breast cancer.3
319197522020Analysis of the DOK1 gene in breast cancer.3
316387422019Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.12
316387422019Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.12
291509482018Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.7
291509482018Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.7
283961482017DOK1/PPARgamma pathway mediates anti-tumor ability of all-trans retinoic acid in breast cancer MCF-7 cells.4
283961482017DOK1/PPARgamma pathway mediates anti-tumor ability of all-trans retinoic acid in breast cancer MCF-7 cells.4
270781522016RASSF1A and DOK1 Promoter Methylation Levels in Hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients.8
272654732016Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.3
274284272016Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.12

Citation

Dessen P

DOK1 (docking protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40356