DSC3 (desmocollin 3)

2003-11-01  

Identity

HGNC
DSC3
LOCATION
18q12.1
LOCUSID
1825
ALIAS
CDHF3,DSC,DSC1,DSC2,DSC4,HT-CP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1825
MIM: 600271
HGNC: 3037
Ensembl: ENSG00000134762

Variants:

dbSNP: 1825
ClinVar: 1825
TCGA: ENSG00000134762
COSMIC: DSC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134762ENST00000360428Q14574
ENSG00000134762ENST00000434452Q14574
ENSG00000134762ENST00000584980J3QRL9

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363058872023Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement.0
386518432023Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study.0
363058872023Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement.0
386518432023Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study.0
337665092021Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2.2
337665092021Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2.2
308579732019Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.9
308579732019Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.9
280941052017Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.5
281549622017Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.2
280941052017Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.5
281549622017Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.2
267109752016The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.2
267109752016The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.2
262615542015Desmocollin 3 mediates follicle stimulating hormone-induced ovarian epithelial cancer cell proliferation by activating the EGFR/Akt signaling pathway.5

Citation

Dessen P

DSC3 (desmocollin 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40364