HBEGF (heparin binding EGF like growth factor)

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HBEGF (heparin binding EGF like growth factor)

2003-02-01 Affiliation

Identity

HGNC

LOCATION

5q31.3

LOCUSID

ALIAS

DTR,DTS,DTSF,HEGFL

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1839
MIM: 126150
HGNC: 3059
Ensembl: ENSG00000113070

Variants:

dbSNP: 1839
ClinVar: 1839
TCGA: ENSG00000113070
COSMIC: HBEGF

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000113070	ENST00000230990	Q99075

Expression (GTEx)

0

50

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
GnRH signaling pathway	KEGG	ko04912
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
Bladder cancer	KEGG	ko05219
ErbB signaling pathway	KEGG	hsa04012
GnRH signaling pathway	KEGG	hsa04912
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Bladder cancer	KEGG	hsa05219
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of diphtheria toxin	REACTOME	R-HSA-5336415
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
PI3K events in ERBB2 signaling	REACTOME	R-HSA-1963642
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
PI3K events in ERBB4 signaling	REACTOME	R-HSA-1250342
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
EGFR Transactivation by Gastrin	REACTOME	R-HSA-2179392
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
ERBB2 Regulates Cell Motility	REACTOME	R-HSA-6785631
ERBB2 Activates PTK6 Signaling	REACTOME	R-HSA-8847993
Signaling by PTK6	REACTOME	R-HSA-8848021
PTK6 promotes HIF1A stabilization	REACTOME	R-HSA-8857538
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

N/A

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10040	cetuximab	Chemical	Pathway	associated
PA162373091	panitumumab	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38409259	2024	The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.	0
38409259	2024	The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.	0
37567873	2023	Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.	3
37567873	2023	Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.	3
36261438	2022	HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids.	17
36261438	2022	HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids.	17
33009641	2021	APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.	11
33400994	2021	Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.	10
34475044	2021	Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth.	4
34814928	2021	microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor.	5
33009641	2021	APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.	11
33400994	2021	Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.	10
34475044	2021	Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth.	4
34814928	2021	microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor.	5
31799884	2020	Circulating levels of inflammatory parameters pentraxin-3, cyclophilin and heparin-binding epidermal growth factor-like growth factor in patients with ST-elevation myocardial infarction.	1

Citation

Dessen P

HBEGF (heparin binding EGF like growth factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40369/cancer-prone-explorer/deep-insight-explorer/js/web-card-gene.js

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