Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1839
MIM: 126150
HGNC: 3059
Ensembl: ENSG00000113070
Variants:
dbSNP: 1839
ClinVar: 1839
TCGA: ENSG00000113070
COSMIC: HBEGF
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113070 | ENST00000230990 | Q99075 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10040 | cetuximab | Chemical | Pathway | associated | |||
| PA162373091 | panitumumab | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38409259 | 2024 | The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. | 0 |
| 38409259 | 2024 | The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. | 0 |
| 37567873 | 2023 | Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. | 3 |
| 37567873 | 2023 | Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. | 3 |
| 36261438 | 2022 | HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids. | 17 |
| 36261438 | 2022 | HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids. | 17 |
| 33009641 | 2021 | APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis. | 11 |
| 33400994 | 2021 | Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients. | 10 |
| 34475044 | 2021 | Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth. | 4 |
| 34814928 | 2021 | microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor. | 5 |
| 33009641 | 2021 | APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis. | 11 |
| 33400994 | 2021 | Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients. | 10 |
| 34475044 | 2021 | Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth. | 4 |
| 34814928 | 2021 | microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor. | 5 |
| 31799884 | 2020 | Circulating levels of inflammatory parameters pentraxin-3, cyclophilin and heparin-binding epidermal growth factor-like growth factor in patients with ST-elevation myocardial infarction. | 1 |
Citation
Dessen P
HBEGF (heparin binding EGF like growth factor)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40369/hbegf
