DTX1 (deltex E3 ubiquitin ligase 1)

2003-11-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
RNF140,hDx-1
FUSION GENES

Other Information

Locus ID:

NCBI: 1840
MIM: 602582
HGNC: 3060
Ensembl: ENSG00000135144

Variants:

dbSNP: 1840
ClinVar: 1840
TCGA: ENSG00000135144
COSMIC: DTX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135144ENST00000257600Q86Y01

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
327004762020Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis.2
327004762020Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis.2
313130372019Genetic Variant of Notch Regulator DTX1 Predicts Survival After Lung Cancer Surgery.3
313130372019Genetic Variant of Notch Regulator DTX1 Predicts Survival After Lung Cancer Surgery.3
293741802018c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.25
294404322018PI5P4Kγ functions in DTX1-mediated Notch signaling.21
297048702018Immune-regulatory genes as possible modifiers of familial pityriasis rubra pilaris - lessons from a family with PRP and psoriasis.4
293741802018c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.25
294404322018PI5P4Kγ functions in DTX1-mediated Notch signaling.21
297048702018Immune-regulatory genes as possible modifiers of familial pityriasis rubra pilaris - lessons from a family with PRP and psoriasis.4
281464322017Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.10
281838502017Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.17
281464322017Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.10
281838502017Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma.17
268949272016Deltex1 Polymorphisms Are Associated with Hepatitis B Vaccination Non-Response in Southwest China.9

Citation

Dessen P

DTX1 (deltex E3 ubiquitin ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40370/dtx1