DUSP22 (dual specificity phosphatase 22)

2003-06-01  

Identity

HGNC
DUSP22
LOCATION
6p25.3
LOCUSID
56940
ALIAS
JKAP,JSP-1,JSP1,LMW-DSP2,LMWDSP2,MKP-x,MKPX,VHX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56940
MIM: 616778
HGNC: 16077
Ensembl: ENSG00000112679

Variants:

dbSNP: 56940
ClinVar: 56940
TCGA: ENSG00000112679
COSMIC: DUSP22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112679ENST00000344450Q9NRW4
ENSG00000112679ENST00000344450A0A384NLC8
ENSG00000112679ENST00000419235Q9NRW4
ENSG00000112679ENST00000603296S4R3A4
ENSG00000112679ENST00000603453S4R3M1
ENSG00000112679ENST00000603726S4R459
ENSG00000112679ENST00000603795S4R459
ENSG00000112679ENST00000603881S4R3K1
ENSG00000112679ENST00000604971S4R3M1
ENSG00000112679ENST00000605035S4R378
ENSG00000112679ENST00000605315S4R3M1
ENSG00000112679ENST00000605863S4R378

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379379152024DUSP22 suppresses tumor progression by directly dephosphorylating AKT in non-small cell lung cancer.0
382252652024The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling.1
384958102024DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways.0
388514182024Exosomal miR-1228-5p down-regulates DUSP22 to promotes cell proliferation and migration in small cell lung cancer.0
379379152024DUSP22 suppresses tumor progression by directly dephosphorylating AKT in non-small cell lung cancer.0
382252652024The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling.1
384958102024DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways.0
388514182024Exosomal miR-1228-5p down-regulates DUSP22 to promotes cell proliferation and migration in small cell lung cancer.0
364531042023DUSP22 rearrangement is associated with a distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma.6
364531052023ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.6
364531062023DUSP22-rearranged ALK-negative anaplastic large cell lymphoma is a pathogenetically distinct disease but can have variable clinical outcome.5
367653052023Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis.3
381799962023Serum JKAP reflects Th2 and Th17 cell levels, and diabetic nephropathy risk and severity in diabetes mellitus patients.0
364531042023DUSP22 rearrangement is associated with a distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma.6
364531052023ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.6

Citation

Dessen P

DUSP22 (dual specificity phosphatase 22)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40373/js/favicon/apple-touch-icon.png