Identity
HGNC
LOCATION
8p12
LOCUSID
ALIAS
HVH2,MKP-2,MKP2,TYP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1846
MIM: 602747
HGNC: 3070
Ensembl: ENSG00000120875
Variants:
dbSNP: 1846
ClinVar: 1846
TCGA: ENSG00000120875
COSMIC: DUSP4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000120875 | ENST00000240100 | Q13115 |
| ENSG00000120875 | ENST00000240101 | Q13115 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38254666 | 2024 | Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease. | 0 |
| 38286920 | 2024 | DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy. | 0 |
| 38254666 | 2024 | Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease. | 0 |
| 38286920 | 2024 | DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy. | 0 |
| 36705792 | 2023 | DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. | 4 |
| 37086337 | 2023 | An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells. | 1 |
| 38071325 | 2023 | ARID1A loss activates MAPK signaling via DUSP4 downregulation. | 0 |
| 36705792 | 2023 | DUSP4 inhibits autophagic cell death and apoptosis in colorectal cancer by regulating BCL2-Beclin1/Bax signaling. | 4 |
| 37086337 | 2023 | An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells. | 1 |
| 38071325 | 2023 | ARID1A loss activates MAPK signaling via DUSP4 downregulation. | 0 |
| 34652441 | 2022 | Long non-coding RNA AFAP1-AS1 promotes thyroid cancer progression by sponging miR-204-3p and upregulating DUSP4. | 2 |
| 35189148 | 2022 | DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells. | 1 |
| 35338857 | 2022 | Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro. | 3 |
| 35745205 | 2022 | Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease. | 1 |
| 35864956 | 2022 | Genome-Wide CRISPR/Cas9 Library Screening Identified that DUSP4 Deficiency Induces Lenvatinib Resistance in Hepatocellular Carcinoma. | 11 |
Citation
Dessen P
DUSP4 (dual specificity phosphatase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/40375/dusp4
