TSKU (tsukushi, small leucine rich proteoglycan)

2003-11-01  

Identity

HGNC
TSKU
LOCATION
11q13.5
LOCUSID
25987
ALIAS
E2IG4,LRRC54,TSK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25987
MIM: 608015
HGNC: 28850
Ensembl: ENSG00000182704

Variants:

dbSNP: 25987
ClinVar: 25987
TCGA: ENSG00000182704
COSMIC: TSKU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182704ENST00000333090Q8WUA8
ENSG00000182704ENST00000333090A0A024R5J8
ENSG00000182704ENST00000525167E9PN12
ENSG00000182704ENST00000527881Q8WUA8
ENSG00000182704ENST00000527881A0A024R5J8
ENSG00000182704ENST00000533752E9PLG7
ENSG00000182704ENST00000612930Q8WUA8
ENSG00000182704ENST00000612930A0A024R5J8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337592202021Novel roles of Tsukushi in signaling pathways and multiple disease processes.4
338604532021Tsukushi and TSKU genotype in obesity and related metabolic disorders.3
337592202021Novel roles of Tsukushi in signaling pathways and multiple disease processes.4
338604532021Tsukushi and TSKU genotype in obesity and related metabolic disorders.3
324429082020Gastric banding-associated weight loss diminishes hepatic Tsukushi expression.1
331172922020Elevated Serum Tsukushi Levels in Patients With Hyperthyroidism.4
324429082020Gastric banding-associated weight loss diminishes hepatic Tsukushi expression.1
331172922020Elevated Serum Tsukushi Levels in Patients With Hyperthyroidism.4
310276862019Significance of Tsukushi in lung cancer.7
313913392019The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.22
310276862019Significance of Tsukushi in lung cancer.7
313913392019The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.22
305505712018microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi.17
305505712018microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi.17
228800132012Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.23

Citation

Dessen P

TSKU (tsukushi, small leucine rich proteoglycan)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40387