Identity
HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
EBAF,LEFTA,LEFTYA,TGFB4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7044
MIM: 601877
HGNC: 3122
Ensembl: ENSG00000143768
Variants:
dbSNP: 7044
ClinVar: 7044
TCGA: ENSG00000143768
COSMIC: LEFTY2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143768 | ENST00000366820 | O00292 |
| ENSG00000143768 | ENST00000366820 | A0A024R3P5 |
| ENSG00000143768 | ENST00000420304 | O00292 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37097539 | 2023 | Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. | 1 |
| 37097539 | 2023 | Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. | 1 |
| 32236143 | 2020 | LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells. | 4 |
| 32745796 | 2020 | LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. | 10 |
| 33111989 | 2020 | Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma. | 4 |
| 32236143 | 2020 | LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells. | 4 |
| 32745796 | 2020 | LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway. | 10 |
| 33111989 | 2020 | Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma. | 4 |
| 30575724 | 2018 | Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty. | 35 |
| 30575724 | 2018 | Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty. | 35 |
| 29268772 | 2017 | A functional role of LEFTY during progesterone therapy for endometrial carcinoma. | 2 |
| 29268772 | 2017 | A functional role of LEFTY during progesterone therapy for endometrial carcinoma. | 2 |
| 27404958 | 2016 | LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells. | 14 |
| 27497669 | 2016 | LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a. | 11 |
| 27606670 | 2016 | LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1. | 6 |
Citation
Dessen P
LEFTY2 (left-right determination factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/40392/lefty2
