Identity
HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
PAI,PAI-1,PAI1,PLANH1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5054
MIM: 173360
HGNC: 8583
Ensembl: ENSG00000106366
Variants:
dbSNP: 5054
ClinVar: 5054
TCGA: ENSG00000106366
COSMIC: SERPINE1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000106366 | ENST00000223095 | P05121 |
| ENSG00000106366 | ENST00000223095 | A0A024QYT5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PD | 18285546 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 18794724 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 18794724 | |
| PA449247 | dexamethasone | Chemical | ClinicalAnnotation | associated | PD | 18285546 | |
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 18794724 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 18794724 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37369886 | 2024 | Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1. | 0 |
| 37758852 | 2024 | Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions. | 0 |
| 38073374 | 2024 | Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response. | 0 |
| 38216379 | 2024 | Thrombotic risk assessed by PAI-1 in patients with COVID-19: The influence of hyperglycemia and diabetes mellitus. | 0 |
| 38251423 | 2024 | Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. | 2 |
| 38266576 | 2024 | Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis. | 0 |
| 38287534 | 2024 | Possible effects of plasminogen activator inhibitor-1 on promoting angiogenesis through matrix metalloproteinase 9 in advanced mycosis fungoides. | 0 |
| 38393683 | 2024 | miR-30d-5p inhibits proliferation, invasion and migration of breast cancer cells by targeting SERPINE1 and promoting fatty acid β-oxidation. | 0 |
| 38608056 | 2024 | A challenging issue in COVID-19 infection: The relationship between PA1-1 and TAFI levels in patients with coagulation disorder: A retrospective and observational study. | 0 |
| 38777211 | 2024 | Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways. | 0 |
| 37369886 | 2024 | Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1. | 0 |
| 37758852 | 2024 | Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions. | 0 |
| 38073374 | 2024 | Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response. | 0 |
| 38216379 | 2024 | Thrombotic risk assessed by PAI-1 in patients with COVID-19: The influence of hyperglycemia and diabetes mellitus. | 0 |
| 38251423 | 2024 | Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. | 2 |
Citation
Dessen P
SERPINE1 (serpin family E member 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/404/serpine1
