EGR2 (early growth response 2)

2003-02-01  

Identity

HGNC
EGR2
LOCATION
10q21.3
LOCUSID
1959
ALIAS
AT591,CHN1,CMT1D,CMT4E,KROX20

Other Information

Locus ID:

NCBI: 1959
MIM: 129010
HGNC: 3239
Ensembl: ENSG00000122877

Variants:

dbSNP: 1959
ClinVar: 1959
TCGA: ENSG00000122877
COSMIC: EGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122877ENST00000242480P11161
ENSG00000122877ENST00000411732P11161
ENSG00000122877ENST00000439032P11161
ENSG00000122877ENST00000637191A0A1B0GUL0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
381656802024MicroRNA-150-5P regulates Th1/Th2 cytokines expression levels by targeting EGR2 in allergic rhinitis.0
386792302024Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.0
381656802024MicroRNA-150-5P regulates Th1/Th2 cytokines expression levels by targeting EGR2 in allergic rhinitis.0
386792302024Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.0
363425112023Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.1
369876652023Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.1
370110082023Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction.5
373069612023EGR2 gene-linked hereditary neuropathies present with a bimodal age distribution at symptoms onset.0
374432842023Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system.0
374746552023EGR2 drives T(H)17 cell pathogenicity in autoimmune neuroinflammation.0
363425112023Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.1
369876652023Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.1
370110082023Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction.5
373069612023EGR2 gene-linked hereditary neuropathies present with a bimodal age distribution at symptoms onset.0
374432842023Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system.0

Citation

Dessen P

EGR2 (early growth response 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40419