Identity
HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
PEK,PERK,WRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9451
MIM: 604032
HGNC: 3255
Ensembl: ENSG00000172071
Variants:
dbSNP: 9451
ClinVar: 9451
TCGA: ENSG00000172071
COSMIC: EIF2AK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000172071 | ENST00000303236 | Q9NZJ5 |
| ENSG00000172071 | ENST00000652099 | A0A494BZR8 |
| ENSG00000172071 | ENST00000652423 | A0A494C186 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37496439 | 2024 | DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | 1 |
| 38789639 | 2024 | Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV. | 0 |
| 37496439 | 2024 | DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | 1 |
| 38789639 | 2024 | Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV. | 0 |
| 36563857 | 2023 | Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation. | 6 |
| 36584479 | 2023 | Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca(2+) and suppressing endoplasmic reticulum stress. | 4 |
| 36696173 | 2023 | Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice. | 0 |
| 36821088 | 2023 | PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration. | 9 |
| 37166058 | 2023 | PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia. | 1 |
| 37197981 | 2023 | Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. | 2 |
| 37536085 | 2023 | Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer. | 8 |
| 37890465 | 2023 | The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells. | 2 |
| 37937642 | 2023 | Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation. | 0 |
| 36563857 | 2023 | Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation. | 6 |
| 36584479 | 2023 | Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca(2+) and suppressing endoplasmic reticulum stress. | 4 |
Citation
Dessen P
EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40424/eif2ak3
