ELAVL4 (ELAV like RNA binding protein 4)

2003-05-01  

Identity

HGNC
ELAVL4
LOCATION
1p33
LOCUSID
1996
ALIAS
HUD,PNEM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1996
MIM: 168360
HGNC: 3315
Ensembl: ENSG00000162374

Variants:

dbSNP: 1996
ClinVar: 1996
TCGA: ENSG00000162374
COSMIC: ELAVL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162374ENST00000357083A0A0R4J2E6
ENSG00000162374ENST00000371819B1APY9
ENSG00000162374ENST00000371821P26378
ENSG00000162374ENST00000371823P26378
ENSG00000162374ENST00000371824P26378
ENSG00000162374ENST00000371827P26378
ENSG00000162374ENST00000448907P26378
ENSG00000162374ENST00000463650A0A494C0Q5
ENSG00000162374ENST00000494555A0A494BZW4
ENSG00000162374ENST00000650764A0A494C1D9
ENSG00000162374ENST00000651258A0A494C015
ENSG00000162374ENST00000651347A0A494C147
ENSG00000162374ENST00000651693A0A494C011
ENSG00000162374ENST00000652274A0A494C0F8
ENSG00000162374ENST00000652353A0A494C173
ENSG00000162374ENST00000652693A0A494C0M6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376767182023ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.1
376767182023ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.1
358433562022RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.4
364989332022Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases.6
358433562022RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.4
364989332022Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases.6
332713272021HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.13
335899242021HuB and HuD repress telomerase activity by dissociating HuR from TERC.5
343147012021ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.58
344712242021ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.19
332713272021HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.13
335899242021HuB and HuD repress telomerase activity by dissociating HuR from TERC.5
343147012021ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.58
344712242021ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.19
312424162019Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.32

Citation

Dessen P

ELAVL4 (ELAV like RNA binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40438/js/lib/js/case-report-explorer/