ELK1 (ETS transcription factor ELK1)

2003-02-01 Affiliation

Identity

HGNC

ELK1

LOCATION

Xp11.23

LOCUSID

2002

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2002
MIM: 311040
HGNC: 3321
Ensembl: ENSG00000126767

Variants:

dbSNP: 2002
ClinVar: 2002
TCGA: ENSG00000126767
COSMIC: ELK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126767	ENST00000247161	P19419
ENSG00000126767	ENST00000247161	A0A024R1A7
ENSG00000126767	ENST00000343894	P19419
ENSG00000126767	ENST00000376983	P19419
ENSG00000126767	ENST00000376983	A0A024R1A7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Focal adhesion	KEGG	ko04510
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Endometrial cancer	KEGG	ko05213
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Focal adhesion	KEGG	hsa04510
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Endometrial cancer	KEGG	hsa05213
Prion diseases	KEGG	ko05020
Prion diseases	KEGG	hsa05020
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hepatitis B	KEGG	hsa05161
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Ras signaling pathway	KEGG	hsa04014
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinases	REACTOME	R-HSA-450282
ERK/MAPK targets	REACTOME	R-HSA-198753
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Nuclear Events (kinase and transcription factor activation)	REACTOME	R-HSA-198725

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA134992438	CAMK1D	Gene	Pathway	associated
PA24684	AKT1	Gene	Pathway	associated
PA24685	AKT2	Gene	Pathway	associated
PA24686	AKT3	Gene	Pathway	associated
PA26048	CAMK1	Gene	Pathway	associated
PA26049	CAMK1G	Gene	Pathway	associated
PA283	MAPK8	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA30622	MAPK3	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA33759	PRKCA	Gene	Pathway	associated
PA33761	PRKCB	Gene	Pathway	associated
PA33766	PRKCG	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA90	CAMK2A	Gene	Pathway	associated
PA91	CAMK2B	Gene	Pathway	associated
PA92	CAMK2D	Gene	Pathway	associated
PA93	CAMK2G	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
36691407	2023	A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.	1
37547727	2023	Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis.	1
36691407	2023	A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.	1
37547727	2023	Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis.	1
35123530	2022	Knockdown of lncRNA LINC00662 suppresses malignant behaviour of osteosarcoma cells via competition with miR-30b-3p to regulate ELK1 expression.	6
35470010	2022	Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.	7
36107384	2022	ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.	0
36575212	2022	The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.	4
35123530	2022	Knockdown of lncRNA LINC00662 suppresses malignant behaviour of osteosarcoma cells via competition with miR-30b-3p to regulate ELK1 expression.	6
35470010	2022	Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.	7
36107384	2022	ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.	0
36575212	2022	The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.	4
33099720	2021	ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis.	6
33247506	2021	c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression.	11
33295145	2021	Elevated microRNA-130b-5p or silenced ELK1 inhibits self-renewal ability, proliferation, migration, and invasion abilities, and promotes apoptosis of cervical cancer stem cells.	4

Citation

Dessen P

ELK1 (ETS transcription factor ELK1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40440/haematological-explorer/favicon/case-report-explorer/