ELL2 (elongation factor for RNA polymerase II 2)

2003-02-01  

Identity

HGNC
ELL2
LOCATION
5q15
LOCUSID
22936
ALIAS
MRCCAT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22936
MIM: 601874
HGNC: 17064
Ensembl: ENSG00000118985

Variants:

dbSNP: 22936
ClinVar: 22936
TCGA: ENSG00000118985
COSMIC: ELL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118985ENST00000237853O00472
ENSG00000118985ENST00000508757H0Y8G1
ENSG00000118985ENST00000513343D6RC27
ENSG00000118985ENST00000635633A0A0U1RR08

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

References

Pubmed IDYearTitleCitations
342652492021Allosteric transcription stimulation by RNA polymerase II super elongation complex.9
349483912021Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation.0
342652492021Allosteric transcription stimulation by RNA polymerase II super elongation complex.9
349483912021Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation.0
291799982018ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells.7
296957192018The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.17
300095042018Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.6
305568822018Upregulation of long noncoding RNA MRCCAT1 predicts poor prognosis and functions as an oncogene in glioma.2
291799982018ELL2 regulates DNA non-homologous end joining (NHEJ) repair in prostate cancer cells.7
296957192018The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.17
300095042018Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.6
305568822018Upregulation of long noncoding RNA MRCCAT1 predicts poor prognosis and functions as an oncogene in glioma.2
281342502017Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.17
285313252017Up-regulated microRNA-299 corrected with poor prognosis of glioblastoma multiforme patients by targeting ELL2.9
288586292017Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.8

Citation

Dessen P

ELL2 (elongation factor for RNA polymerase II 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40445/gene-explorer/favicon/favicon/favicon-16x16.png