EPHA4 (EPH receptor A4)

2003-11-01  

Identity

HGNC
EPHA4
LOCATION
2q36.1
LOCUSID
2043
ALIAS
EK8,HEK8,SEK,TYRO1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2043
MIM: 602188
HGNC: 3388
Ensembl: ENSG00000116106

Variants:

dbSNP: 2043
ClinVar: 2043
TCGA: ENSG00000116106
COSMIC: EPHA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116106ENST00000281821P54764
ENSG00000116106ENST00000281821A0A024R452
ENSG00000116106ENST00000409854E9PG71
ENSG00000116106ENST00000409938P54764
ENSG00000116106ENST00000409938A0A024R452
ENSG00000116106ENST00000415749F8WBU0
ENSG00000116106ENST00000419964C9JEM6
ENSG00000116106ENST00000424339H7C2W7
ENSG00000116106ENST00000434266C9JIX8
ENSG00000116106ENST00000441679H7C1N8
ENSG00000116106ENST00000443796C9JFX5
ENSG00000116106ENST00000541600F5GZZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368049382023EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity.1
374777862023Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases.2
368049382023EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity.1
374777862023Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases.2
349890462022Mechanistic and therapeutic implications of EphA-4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.4
357623962022EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1/RhoA/ROCK signaling pathway.6
349890462022Mechanistic and therapeutic implications of EphA-4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.4
357623962022EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1/RhoA/ROCK signaling pathway.6
337410232021Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4.14
338133772021Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.6
341392382021A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.11
337410232021Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4.14
338133772021Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.6
341392382021A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.11
330905692020EphA4 regulates Aβ production via BACE1 expression in neurons.4

Citation

Dessen P

EPHA4 (EPH receptor A4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40464