Identity
HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
EPHX,EPOX,HYL1,MEH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2052
MIM: 132810
HGNC: 3401
Ensembl: ENSG00000143819
Variants:
dbSNP: 2052
ClinVar: 2052
TCGA: ENSG00000143819
COSMIC: EPHX1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443223 | Congenital Abnormalities | Disease | ClinicalAnnotation | associated | PD | 19952982 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PK | PD | 20157331 |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 15692831, 19620853, 22188362, 25495409, 26314341 |
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24533712 | |
| PA446836 | Craniofacial Abnormalities | Disease | ClinicalAnnotation | associated | PD | 19952982 | |
| PA448785 | carbamazepine | Chemical | ClinicalAnnotation | associated | PK | PD | 15692831, 19620853, 22188362, 25495409, 26314341 |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 24533712 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 24533712 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation | associated | PK | PD | 20157331 |
| PA450921 | phenprocoumon | Chemical | ClinicalAnnotation | associated | PK | PD | 21057703 |
| PA450947 | phenytoin | Chemical | ClinicalAnnotation | associated | PD | 19952982 | |
| PA451906 | warfarin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 19794411, 21192345, 21593757, 23061746 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33586574 | 2022 | Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis. | 0 |
| 36591768 | 2022 | EPOXID HYDROLASE SINGLE GENE POLYMORPHISM (RS1051740) AND SEVERITY OF CHRONIC OBSTRUCTIVE DISEASE. | 0 |
| 33586574 | 2022 | Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis. | 0 |
| 36591768 | 2022 | EPOXID HYDROLASE SINGLE GENE POLYMORPHISM (RS1051740) AND SEVERITY OF CHRONIC OBSTRUCTIVE DISEASE. | 0 |
| 33567578 | 2021 | Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury. | 7 |
| 34066758 | 2021 | Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. | 14 |
| 34342583 | 2021 | EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. | 11 |
| 34411648 | 2021 | ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients. | 1 |
| 34672683 | 2021 | Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy. | 0 |
| 33567578 | 2021 | Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury. | 7 |
| 34066758 | 2021 | Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. | 14 |
| 34342583 | 2021 | EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. | 11 |
| 34411648 | 2021 | ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients. | 1 |
| 34672683 | 2021 | Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy. | 0 |
| 31566711 | 2020 | LINC00205 modulates the expression of EPHX1 through the inhibition of miR-184 in hepatocellular carcinoma as a ceRNA. | 10 |
Citation
Dessen P
EPHX1 (epoxide hydrolase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40472/ephx1
