LIMA1 (LIM domain and actin binding 1)

2003-02-01  

Identity

HGNC
LIMA1
LOCATION
12q13.12
LOCUSID
51474
ALIAS
EPLIN,LDLCQ8,SREBP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51474
MIM: 608364
HGNC: 24636
Ensembl: ENSG00000050405

Variants:

dbSNP: 51474
ClinVar: 51474
TCGA: ENSG00000050405
COSMIC: LIMA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050405ENST00000341247Q9UHB6
ENSG00000050405ENST00000394943Q9UHB6
ENSG00000050405ENST00000547825Q9UHB6
ENSG00000050405ENST00000550592F8VVQ7
ENSG00000050405ENST00000551691F8VTU2
ENSG00000050405ENST00000552491F8VS07
ENSG00000050405ENST00000552720F8VRN8
ENSG00000050405ENST00000552783Q9UHB6
ENSG00000050405ENST00000552823Q9UHB6
ENSG00000050405ENST00000552909F8VQE1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381852512024Nuclear-cytoplasmic translocation of SQSTM1/p62 protein enhances ESCC cell migration and invasion by stabilizing EPLIN expression.1
387197522024The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts.0
381852512024Nuclear-cytoplasmic translocation of SQSTM1/p62 protein enhances ESCC cell migration and invasion by stabilizing EPLIN expression.1
387197522024The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts.0
373259742023EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.1
377522332023MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.3
373259742023EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.1
377522332023MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.3
364971152022CAF-Released Exosomal miR-20a-5p Facilitates HCC Progression via the LIMA1-Mediated β-Catenin Pathway.13
364971152022CAF-Released Exosomal miR-20a-5p Facilitates HCC Progression via the LIMA1-Mediated β-Catenin Pathway.13
339991012021Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration.11
343566622021Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers.10
339991012021Rab40-Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration.11
343566622021Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers.10
324965612020LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation.14

Citation

Dessen P

LIMA1 (LIM domain and actin binding 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40474